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    Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685729, updated on 27-Nov-2024

    Summary

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    Symbol
    Pcbd2provided by RGD
    Full Name
    pterin-4 alpha-carbinolamine dehydratase 2provided by RGD
    Primary source
    RGD:1590239
    See related
    AllianceGenome:RGD:1590239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; identical protein binding activity; and phenylalanine 4-monooxygenase activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in mitochondrion and nucleus. Orthologous to human PCBD2 (pterin-4 alpha-carbinolamine dehydratase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 134.7), Kidney (RPKM 105.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcbd2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (8850349..8902420, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (8845161..8896343, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (8929675..8980712, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 3 Neighboring gene uncharacterized LOC134482674 Neighboring gene thioredoxin domain containing 15 Neighboring gene similar to human chromosome 5 open reading frame 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2. Rose RB, et al. Biochemistry, 2004 Jun 15. PMID 15182178
    2. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. Lim S, et al. J Biol Chem, 2002 Jul 12. PMID 11980910
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phenylalanine 4-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine biosynthetic process, by oxidation of phenylalanine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pterin-4-alpha-carbinolamine dehydratase 2
    Names
    dimerization cofactor of hepatocyte nuclear factor 1 alpha 2
    pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
    NP_001389423.1
    XP_038952380.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402494.1 → NP_001389423.1  pterin-4-alpha-carbinolamine dehydratase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      8850349..8902420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096452.2 → XP_038952380.1  pterin-4-alpha-carbinolamine dehydratase 2 isoform X1

      Conserved Domains (1) summary
      cl00942
      Location:30 → 72
      PCD_DCoH; The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating ...

    RNA

    1. XR_010058946.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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