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    Pgm3 phosphoglucomutase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363109, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pgm3provided by RGD
    Official Full Name
    phosphoglucomutase 3provided by RGD
    Primary source
    RGD:1305221
    See related
    EnsemblRapid:ENSRNOG00000009515 AllianceGenome:RGD:1305221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphoacetylglucosamine mutase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process; hemopoiesis; and protein glycosylation. Predicted to act upstream of or within spermatogenesis. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 100.0), Brain (RPKM 71.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgm3 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (96398331..96416045, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (87518317..87536021, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94225513..94243230, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3D Neighboring gene stathmin-like Neighboring gene DOP1 leucine zipper like protein A Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment. Zhang Y, et al. J Allergy Clin Immunol, 2014 May. PMID 24589341, Free PMC Article
    2. Gene loss in human teratomas. Linder D. Proc Natl Acad Sci U S A, 1969 Jul. PMID 5259759, Free PMC Article
    3. Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Greig KT, et al. Mol Cell Biol, 2007 Aug. PMID 17548465, Free PMC Article
    4. Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Mio T, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004509
    5. Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer. Marshall MJ, et al. Br J Cancer, 1979 Sep. PMID 508567, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoacetylglucosamine mutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoacetylglucosamine mutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphoacetylglucosamine mutase
    NP_001388122.1
    XP_008764673.1
    XP_063121858.1
    XP_063121859.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401193.1 → NP_001388122.1  phosphoacetylglucosamine mutase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A9K3Y705, B2RYN0, D3ZFX4
      Related
      ENSRNOP00000062246.2, ENSRNOT00000067699.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      96398331..96416045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265788.1 → XP_063121858.1  phosphoacetylglucosamine mutase isoform X1

      UniProtKB/TrEMBL
      A6I1U8
      Related
      ENSRNOP00000110340.1, ENSRNOT00000136792.1

    2. XM_063265789.1 → XP_063121859.1  phosphoacetylglucosamine mutase isoform X2

      UniProtKB/TrEMBL
      A0A9K3Y705, B2RYN0, D3ZFX4

    3. XM_008766451.4 → XP_008764673.1  phosphoacetylglucosamine mutase isoform X1

      See identical proteins and their annotated locations for XP_008764673.1

      UniProtKB/TrEMBL
      A6I1U8, A6I1U9
      Conserved Domains (2) summary
      cd03086
      Location:22 → 525
      PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...
      PLN02895
      Location:1 → 523
      PLN02895; phosphoacetylglucosamine mutase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108772.1: Suppressed sequence

      Description
      NM_001108772.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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