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    Katnal1 katanin catalytic subunit A1 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288449, updated on 27-Nov-2024

    Summary

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    Symbol
    Katnal1provided by RGD
    Full Name
    katanin catalytic subunit A1 like 1provided by RGD
    Primary source
    RGD:1359252
    See related
    EnsemblRapid:ENSRNOG00000047618 AllianceGenome:RGD:1359252
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; identical protein binding activity; and microtubule severing ATPase activity. Predicted to be involved in microtubule severing. Predicted to act upstream of or within spermatogenesis. Predicted to be located in cytoplasm; microtubule; and spindle pole. Predicted to be part of katanin complex. Predicted to be active in microtubule cytoskeleton. Orthologous to human KATNAL1 (katanin catalytic subunit A1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 70.4), Brain (RPKM 69.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Katnal1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (11130935..11192330)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (6094663..6156114)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (7495436..7550205)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554603 Neighboring gene uncharacterized LOC134481258 Neighboring gene ribosomal protein L35A, pseudogene 8 Neighboring gene uncharacterized LOC102554734 Neighboring gene uncharacterized LOC102553253 Neighboring gene uncharacterized LOC108352416 Neighboring gene uncharacterized LOC134478827

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility. Smith LB, et al. PLoS Genet, 2012. PMID 22654668, Free PMC Article
    2. Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing. Cheung K, et al. Mol Cell Proteomics, 2016 May. PMID 26929214, Free PMC Article
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule severing ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule severing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule severing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule severing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of katanin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    katanin p60 ATPase-containing subunit A-like 1
    Names
    katanin p60 ATPase-containing subunit A-like 1-like
    katanin p60 subunit A-like 1
    p60 katanin-like 1
    NP_001006957.1
    XP_006248878.1
    XP_006248879.1
    XP_017453970.1
    XP_017453971.1
    XP_038945085.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006956.1 → NP_001006957.1  katanin p60 ATPase-containing subunit A-like 1

      See identical proteins and their annotated locations for NP_001006957.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083673
      UniProtKB/Swiss-Prot
      Q5XIK7
      UniProtKB/TrEMBL
      A6K183
      Related
      ENSRNOP00000068753.1, ENSRNOT00000077328.3
      Conserved Domains (3) summary
      pfam09336
      Location:448 → 486
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:400 → 444
      AAA_lid_3; AAA+ lid domain
      cd19522
      Location:207 → 376
      RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      11130935..11192330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248817.5 → XP_006248879.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006248879.1

      UniProtKB/Swiss-Prot
      Q5XIK7
      UniProtKB/TrEMBL
      A6K183
      Conserved Domains (3) summary
      pfam09336
      Location:448 → 486
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:400 → 444
      AAA_lid_3; AAA+ lid domain
      cd19522
      Location:207 → 376
      RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

    2. XM_017598482.3 → XP_017453971.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5XIK7
      UniProtKB/TrEMBL
      A6K183
      Conserved Domains (3) summary
      pfam09336
      Location:448 → 486
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:400 → 444
      AAA_lid_3; AAA+ lid domain
      cd19522
      Location:207 → 376
      RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

    3. XM_017598481.3 → XP_017453970.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5XIK7
      UniProtKB/TrEMBL
      A6K183
      Conserved Domains (3) summary
      pfam09336
      Location:448 → 486
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:400 → 444
      AAA_lid_3; AAA+ lid domain
      cd19522
      Location:207 → 376
      RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

    4. XM_006248816.5 → XP_006248878.1  katanin p60 ATPase-containing subunit A-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006248878.1

      UniProtKB/Swiss-Prot
      Q5XIK7
      UniProtKB/TrEMBL
      A6K183
      Conserved Domains (3) summary
      pfam09336
      Location:448 → 486
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:400 → 444
      AAA_lid_3; AAA+ lid domain
      cd19522
      Location:207 → 376
      RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1

    5. XM_039089157.2 → XP_038945085.1  katanin p60 ATPase-containing subunit A-like 1 isoform X2

      Conserved Domains (3) summary
      pfam09336
      Location:282 → 320
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:234 → 278
      AAA_lid_3; AAA+ lid domain
      cd19522
      Location:41 → 210
      RecA-like_KTNA1; Katanin p60 ATPase-containing subunit A1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIK7.1 GenPept UniProtKB/Swiss-Prot:Q5XIK7

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