Dop1a DOP1 leucine zipper like protein A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dop1aprovided by RGD
Official Full Name: DOP1 leucine zipper like protein Aprovided by RGD
Primary source: RGD:1305534
See related: EnsemblRapid:ENSRNOG00000022847 AllianceGenome:RGD:1305534
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dopey1; RGD1305534
Summary: Predicted to be involved in Golgi to endosome transport. Located in Golgi-associated vesicle. Orthologous to human DOP1A (DOP1 leucine zipper like protein A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 168.0), Brain (RPKM 124.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (96295302..96397951)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (87415266..87517935)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (94122733..94225131)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results highlighted the importance of Dopey1 for the development and maintenance of central nervous system myelin
Title: The VF rat with abnormal myelinogenesis has a mutation in Dopey1.

Submit: New GeneRIF Correction

General gene information

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Markers

D9Mit111 (e-PCR), detects polymorphism
- UniSTS:116771

BF386701 (e-PCR)
- UniSTS:243822

RH133183 (e-PCR)
- UniSTS:216466

RH135322 (e-PCR)
- UniSTS:218599

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein dopey-1

Names: dopey family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427274.1 → NP_001414203.1 protein dopey-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

Related

ENSRNOP00000083794.2, ENSRNOT00000114743.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

96295302..96397951

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596105.3 → XP_017451594.1 protein dopey-1 isoform X1

UniProtKB/TrEMBL

D4A0Y2
XM_017596108.3 → XP_017451597.1 protein dopey-1 isoform X3

UniProtKB/TrEMBL

D4A0Y2

Related

ENSRNOP00000014783.8, ENSRNOT00000014783.10
XM_017596107.3 → XP_017451596.1 protein dopey-1 isoform X2

UniProtKB/TrEMBL

D4A0Y2
XM_039082549.2 → XP_038938477.1 protein dopey-1 isoform X5

UniProtKB/TrEMBL

D4A0Y2

Related

ENSRNOP00000102517.1, ENSRNOT00000143181.1

Conserved Domains (2) summary

pfam04118
Location:13 → 297

Dopey_N; Dopey, N-terminal

cl04407
Location:2078 → 2314

Dopey_N; Dopey, N-terminal
XM_006243503.5 → XP_006243565.1 protein dopey-1 isoform X4

See identical proteins and their annotated locations for XP_006243565.1

UniProtKB/TrEMBL

A0A8I6A0N6, D4A0Y2

Conserved Domains (2) summary

pfam04118
Location:13 → 300

Dopey_N; Dopey, N-terminal

cl04407
Location:2079 → 2315

Dopey_N; Dopey, N-terminal
XM_063265561.1 → XP_063121631.1 protein dopey-1 isoform X2
XM_017596106.3 → XP_017451595.1 protein dopey-1 isoform X1

UniProtKB/TrEMBL

D4A0Y2
XM_039082550.2 → XP_038938478.1 protein dopey-1 isoform X6

Conserved Domains (1) summary

cl04407
Location:1525 → 1761

Dopey_N; Dopey, N-terminal