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    IGFL2 IGF like family member 2 [ Homo sapiens (human) ]

    Gene ID: 147920, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IGFL2provided by HGNC
    Official Full Name
    IGF like family member 2provided by HGNC
    Primary source
    HGNC:HGNC:32929
    See related
    Ensembl:ENSG00000204866 MIM:610545; AllianceGenome:HGNC:32929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ645; VPRI645
    Summary
    IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in skin (RPKM 2.9) and testis (RPKM 1.1) See more
    Orthologs
    all
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    Genomic context

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    See IGFL2 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46078513..46215362)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48905965..49042808)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46651039..46664546)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46535831-46536434 Neighboring gene IGF like family member 4 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46636065-46636896 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:46636897-46637728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46637729-46638559 Neighboring gene IGF like family member 3 Neighboring gene TGFB induced factor homeobox 1 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:46662347-46663546 Neighboring gene uncharacterized LOC105372424 Neighboring gene NANOG hESC enhancer GRCh37_chr19:46673889-46674439 Neighboring gene Sharpr-MPRA regulatory region 10795 Neighboring gene IGFL2 antisense RNA 1 Neighboring gene IGF like family member 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 8129 Neighboring gene uncharacterized LOC93429 Neighboring gene MPRA-validated peak3520 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:46732347-46733546 Neighboring gene ribosomal protein L12 pseudogene 41 Neighboring gene IGF like family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. Emtage P, et al. Genomics, 2006 Oct. PMID 16890402
    2. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. Lobito AA, et al. J Biol Chem, 2011 May 27. PMID 21454693, Free PMC Article
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AC007193.6

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin growth factor-like family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002915.3 → NP_001002915.2  insulin growth factor-like family member 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001002915.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC007785, AW009166, AY672112, BC130490
      Consensus CDS
      CCDS46122.1
      UniProtKB/Swiss-Prot
      Q6UWQ7
      Related
      ENSP00000395219.1, ENST00000434646.6
      Conserved Domains (1) summary
      pfam14653
      Location:41 → 123
      IGFL; Insulin growth factor-like family

    2. NM_001135113.2 → NP_001128585.1  insulin growth factor-like family member 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001128585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) that has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC007785, AW009166, AY358692, BC130490
      Consensus CDS
      CCDS46121.1
      UniProtKB/Swiss-Prot
      E9PAV1, Q6B9Z3, Q6UWQ7
      Related
      ENSP00000366922.3, ENST00000377693.5
      Conserved Domains (1) summary
      pfam14653
      Location:24 → 112
      IGFL; Insulin growth factor-like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46078513..46215362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438228.1 → XP_047294184.1  insulin growth factor-like family member 2 isoform X2

    2. XM_024451381.2 → XP_024307149.1  insulin growth factor-like family member 2 isoform X2

      Conserved Domains (1) summary
      pfam14653
      Location:41 → 123
      IGFL; Insulin growth factor-like family

    3. XM_047438227.1 → XP_047294183.1  insulin growth factor-like family member 2 isoform X1

    RNA

    1. XR_007066605.1 RNA Sequence

    2. XR_935743.3 RNA Sequence

    3. XR_001753605.1 RNA Sequence

    4. XR_001753604.1 RNA Sequence

    5. XR_007066604.1 RNA Sequence

    6. XR_007066606.1 RNA Sequence

    7. XR_007066608.1 RNA Sequence

    8. XR_007066610.1 RNA Sequence

    9. XR_002958257.2 RNA Sequence

    10. XR_007066607.1 RNA Sequence

    11. XR_007066612.1 RNA Sequence

    12. XR_007066609.1 RNA Sequence

    13. XR_007066614.1 RNA Sequence

    14. XR_007066615.1 RNA Sequence

    15. XR_007066611.1 RNA Sequence

    16. XR_007066613.1 RNA Sequence

    17. XR_002958269.2 RNA Sequence

    18. XR_007066616.1 RNA Sequence

    19. XR_007066617.1 RNA Sequence

    20. XR_002958271.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48905965..49042808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319899.1 → XP_054175874.1  insulin growth factor-like family member 2 isoform X2

    2. XM_054319904.1 → XP_054175879.1  insulin growth factor-like family member 2 isoform X2

    3. XM_054319900.1 → XP_054175875.1  insulin growth factor-like family member 2 isoform X2

    4. XM_054319905.1 → XP_054175880.1  insulin growth factor-like family member 2 isoform X2

    5. XM_054319901.1 → XP_054175876.1  insulin growth factor-like family member 2 isoform X2

    6. XM_054319903.1 → XP_054175878.1  insulin growth factor-like family member 2 isoform X1

    7. XM_054319902.1 → XP_054175877.1  insulin growth factor-like family member 2 isoform X2

    RNA

    1. XR_008485090.1 RNA Sequence

    2. XR_008485089.1 RNA Sequence

    3. XR_008485088.1 RNA Sequence

    4. XR_008485091.1 RNA Sequence

    5. XR_008485094.1 RNA Sequence

    6. XR_008485096.1 RNA Sequence

    7. XR_008485093.1 RNA Sequence

    8. XR_008485092.1 RNA Sequence

    9. XR_008485098.1 RNA Sequence

    10. XR_008485095.1 RNA Sequence

    11. XR_008485100.1 RNA Sequence

    12. XR_008485102.1 RNA Sequence

    13. XR_008485097.1 RNA Sequence

    14. XR_008485099.1 RNA Sequence

    15. XR_008485101.1 RNA Sequence

    16. XR_008485103.1 RNA Sequence

    17. XR_008485104.1 RNA Sequence

    18. XR_007089175.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWQ7.1 GenPept UniProtKB/Swiss-Prot:Q6UWQ7

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