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    PAIP2 poly(A) binding protein interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 51247, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PAIP2provided by HGNC
    Official Full Name
    poly(A) binding protein interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17970
    See related
    Ensembl:ENSG00000120727 MIM:605604; AllianceGenome:HGNC:17970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAIP-2; PAIP2A
    Summary
    Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAIP2 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139341854..139369717)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139867910..139895795)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138677543..138705406)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene matrin 3 Neighboring gene Sharpr-MPRA regulatory region 13556 Neighboring gene RNA, 5S ribosomal pseudogene 195 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:138657767-138658966 Neighboring gene RN7SK pseudogene 64 Neighboring gene solute carrier family 23 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138716531-138717471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138723739-138724286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724287-138724834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724835-138725382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16409 Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16411 Neighboring gene spermatogenesis associated 24 Neighboring gene marginal zone B and B1 cell specific protein Neighboring gene proline rich basic protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the C-terminal PABC domain of human poly(A)-binding protein. Kozlov G, et al. Proc Natl Acad Sci U S A, 2001 Apr 10. PMID 11287632, Free PMC Article
    2. Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination. Ivanov A, et al. J Biol Chem, 2019 May 24. PMID 30992367, Free PMC Article
    3. A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication. McKinney C, et al. Genes Dev, 2013 Aug 15. PMID 23964095, Free PMC Article
    4. Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Khaleghpour K, et al. Mol Cell Biol, 2001 Aug. PMID 11438674, Free PMC Article
    5. Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Gouyon F, et al. Biochem J, 2003 Oct 1. PMID 12820898, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicated that PAIP1 and PAIP2 participate in translation termination and are important regulators of readthrough at the premature termination codon.
      Title: Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination.
    2. Paip2 is a host antiviral restriction factor antagonized by PABP accumulation in HCMV-infected cells
      Title: A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
    4. Role of PAIP2 in modulation of GLUT5 mRNA stability.
      Title: Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.
    5. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis
      Title: Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.
    6. The turnover of Paip2 in the cell is mediated by EDD and is regulated by PABP.
      Title: Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyadenylate-binding protein-interacting protein 2
    Names
    PABC1-interacting protein 2
    PABP-interacting protein 2
    polyA-binding protein-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033112.3 → NP_001028284.1  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_001028284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC039337, BC062718, BU732743
      Consensus CDS
      CCDS4211.1
      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Related
      ENSP00000422508.1, ENST00000510080.1
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    2. NM_016480.5 → NP_057564.3  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_057564.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC039337, BI552800, BU732743
      Consensus CDS
      CCDS4211.1
      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Related
      ENSP00000265192.4, ENST00000265192.9
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    RNA

    1. NR_109830.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC039337, BI552800, BU732743

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      139341854..139369717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009522.2 → XP_016865011.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Related
      ENSP00000378275.2, ENST00000394795.6
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    2. XM_011543428.2 → XP_011541730.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011541730.1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    3. XM_047417265.1 → XP_047273221.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7

    4. XM_047417266.1 → XP_047273222.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7

    5. XM_017009523.3 → XP_016865012.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139867910..139895795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352722.1 → XP_054208697.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7

    2. XM_054352723.1 → XP_054208698.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7

    3. XM_054352724.1 → XP_054208699.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7

    4. XM_054352725.1 → XP_054208700.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBI1, D3DQC6, Q49A06, Q9BPZ3, Q9H0Y5, Q9P0Q8
      UniProtKB/TrEMBL
      Q49AE6, Q6FID7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BPZ3.1 GenPept UniProtKB/Swiss-Prot:Q9BPZ3

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