TYR1 prephenate dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TYR1
Official Full Name: prephenate dehydrogenase (NADP(+))
Primary source: SGD:S000000370
Locus tag: YBR166C
See related: AllianceGenome:SGD:S000000370; FungiDB:YBR166C; VEuPathDB:YBR166C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables prephenate dehydrogenase (NAD+) activity. Involved in tyrosine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TYR1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (569842..571200, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables prephenate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables prephenate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables prephenate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables prephenate dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prephenate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tyrosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tyrosine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tyrosine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

General protein information

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Preferred Names: prephenate dehydrogenase (NADP(+))

NP_009725.1

EC 1.3.1.13

Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

569842..571200 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178514.1 → NP_009725.1 TPA: prephenate dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009725.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQG2, P20049

UniProtKB/TrEMBL

G2W9G9, N1P8K9

Conserved Domains (1) summary

COG0287
Location:11 → 288

TyrA; Prephenate dehydrogenase [Amino acid transport and metabolism]