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    Kidins220 kinase D-interacting substrate 220 [ Mus musculus (house mouse) ]

    Gene ID: 77480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kidins220provided by MGI
    Official Full Name
    kinase D-interacting substrate 220provided by MGI
    Primary source
    MGI:MGI:1924730
    See related
    Ensembl:ENSMUSG00000036333 AllianceGenome:MGI:1924730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1250; 3110039L19Rik; C330002I19Rik
    Summary
    Predicted to enable PDZ domain binding activity; protein kinase binding activity; and protein kinase regulator activity. Acts upstream of or within dendrite morphogenesis and in utero embryonic development. Predicted to be located in late endosome. Predicted to be part of protein-containing complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human KIDINS220 (kinase D interacting substrate 220). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 54.8), whole brain E14.5 (RPKM 42.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kidins220 in Genome Data Viewer
    Location:
    12 A1.3; 12 8.54 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (25024909..25113151)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24974903..25063152)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060N12 gene Neighboring gene STARR-seq mESC enhancer starr_31760 Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E5324 Neighboring gene predicted gene, 36236 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25695412-25695595 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25777982-25778091 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25780927-25781228 Neighboring gene inhibitor of DNA binding 2 Neighboring gene predicted gene, 17746

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis. Del Puerto A, et al. Cell Death Dis, 2023 Aug 4. PMID 37542079, Free PMC Article
    2. A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Duffy AM, et al. Exp Neurol, 2011 Jun. PMID 21419124, Free PMC Article
    3. Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons. Scholz-Starke J, et al. PLoS One, 2012. PMID 22563401, Free PMC Article
    4. Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development. Higuero AM, et al. J Biol Chem, 2010 Jan 8. PMID 19903810, Free PMC Article
    5. Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development. Chen Y, et al. J Neurosci, 2012 Jun 13. PMID 22699907, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
      Title: Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals.
    2. Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis.
      Title: Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis.
    3. ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion.
      Title: ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion.
    4. Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
      Title: Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
    5. A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor.
      Title: A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor.
    6. Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
      Title: Kidins220/ARMS controls astrocyte calcium signaling and neuron-astrocyte communication.
    7. Kidins220 has a prominent role in tumor development by participating in a complex signaling pathways. (Review)
      Title: Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review).
    8. Kidins220 binds to the B cell antigen receptor and regulates B cell development and activation.
      Title: Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
    9. the existence of novel Kidins220/ARMS splice isoforms with unique properties
      Title: Novel Kidins220/ARMS Splice Isoforms: Potential Specific Regulators of Neuronal and Cardiovascular Development.
    10. The scaffold protein Kidins220 associates with brain voltage-gated sodium channels and modulates their activity.
      Title: Functional Interaction between the Scaffold Protein Kidins220/ARMS and Neuronal Voltage-Gated Na+ Channels.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nerve growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinase D-interacting substrate of 220 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081378.2 → NP_001074847.1  kinase D-interacting substrate of 220 kDa isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC159307, CT010478
      Consensus CDS
      CCDS36424.1
      UniProtKB/TrEMBL
      E9Q9B7
      Related
      ENSMUSP00000063999.6, ENSMUST00000066652.7
      Conserved Domains (5) summary
      PHA02736
      Location:348 → 412
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 377
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:440 → 953
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    2. NM_001418114.1 → NP_001405043.1  kinase D-interacting substrate of 220 kDa isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159307, CT010478

    3. NM_001418115.1 → NP_001405044.1  kinase D-interacting substrate of 220 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159307, CT010478
      Related
      ENSMUSP00000152726.2, ENSMUST00000220459.2

    4. NM_001418116.1 → NP_001405045.1  kinase D-interacting substrate of 220 kDa isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159307, CT010478

    5. NM_001418117.1 → NP_001405046.1  kinase D-interacting substrate of 220 kDa isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159307, CT010478

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      25024909..25113151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515259.4 → XP_006515322.1  kinase D-interacting substrate of 220 kDa isoform X11

      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    2. XM_006515260.5 → XP_006515323.1  kinase D-interacting substrate of 220 kDa isoform X12

      Related
      ENSMUSP00000152399.2, ENSMUST00000222013.2
      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    3. XM_017315243.3 → XP_017170732.1  kinase D-interacting substrate of 220 kDa isoform X13

      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    4. XM_017315244.3 → XP_017170733.1  kinase D-interacting substrate of 220 kDa isoform X14

      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    5. XM_006515250.5 → XP_006515313.1  kinase D-interacting substrate of 220 kDa isoform X1

      See identical proteins and their annotated locations for XP_006515313.1

      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    6. XM_030246980.2 → XP_030102840.1  kinase D-interacting substrate of 220 kDa isoform X2

      UniProtKB/TrEMBL
      E9Q9B7
      Conserved Domains (5) summary
      PHA02736
      Location:348 → 412
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 377
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:440 → 953
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    7. XM_006515251.5 → XP_006515314.1  kinase D-interacting substrate of 220 kDa isoform X1

      See identical proteins and their annotated locations for XP_006515314.1

      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    8. XM_036157660.1 → XP_036013553.1  kinase D-interacting substrate of 220 kDa isoform X3

      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    9. XM_036157663.1 → XP_036013556.1  kinase D-interacting substrate of 220 kDa isoform X8

      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    10. XM_036157661.1 → XP_036013554.1  kinase D-interacting substrate of 220 kDa isoform X4

      Conserved Domains (5) summary
      PHA02736
      Location:348 → 412
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 377
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:440 → 953
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    11. XM_006515254.5 → XP_006515317.1  kinase D-interacting substrate of 220 kDa isoform X5

      UniProtKB/TrEMBL
      A0A1Y7VME9
      Related
      ENSMUSP00000152683.2, ENSMUST00000222941.2
      Conserved Domains (5) summary
      PHA02736
      Location:348 → 412
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 377
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:440 → 953
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    RNA

    1. XR_004937557.1 RNA Sequence

    2. XR_004937558.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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