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    Mip major intrinsic protein of lens fiber [ Mus musculus (house mouse) ]

    Gene ID: 17339, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mipprovided by MGI
    Official Full Name
    major intrinsic protein of lens fiberprovided by MGI
    Primary source
    MGI:MGI:96990
    See related
    Ensembl:ENSMUSG00000025389 AllianceGenome:MGI:96990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cat; Cts; Hfi; Lop; Svl; Aqp0; MP26; MIP26; shrivelled
    Summary
    Enables water channel activity. A structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye; visual perception; and water transport. Located in plasma membrane. Is expressed in several structures, including eye; femur; and main olfactory bulb. Used to study cataract 15 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Mip in Genome Data Viewer
    Location:
    10 D3; 10 76.49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128061679..128067681)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128225810..128231812)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11760 Neighboring gene predicted gene 4556 Neighboring gene glutaminase 2 (liver, mitochondrial) Neighboring gene STARR-positive B cell enhancer ABC_E725 Neighboring gene STARR-positive B cell enhancer ABC_E10659 Neighboring gene SPRY domain containing 4 Neighboring gene predicted gene, 26847 Neighboring gene timeless circadian clock 1 Neighboring gene STARR-seq mESC enhancer starr_28273 Neighboring gene apolipoprotein N

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cell adhesion mediator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables channel activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of eye lens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables water channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in canalicular bile acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell communication NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in gap junction-mediated intercellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gap junction-mediated intercellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of lens transparency ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within water transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in water transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in water transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    lens fiber major intrinsic protein
    Names
    aquaporin-0
    cataract and small eye
    dominant cataract
    hydropic fibers
    lens opacity
    major intrinsic protein of eye lens fiber
    NP_032626.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008600.5NP_032626.2  lens fiber major intrinsic protein

      See identical proteins and their annotated locations for NP_032626.2

      Status: VALIDATED

      Source sequence(s)
      AI323353, AK136287, BB651737
      Consensus CDS
      CCDS24265.1
      UniProtKB/Swiss-Prot
      O00285, P51180, Q3UWJ9, Q8BHA2
      UniProtKB/TrEMBL
      Q640N8
      Related
      ENSMUSP00000026455.8, ENSMUST00000026455.8
      Conserved Domains (1) summary
      pfam00230
      Location:3219
      MIP; Major intrinsic protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128061679..128067681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)