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    PAA1 polyamine acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PAA1
    Official Full Name
    polyamine acetyltransferase
    Primary source
    SGD:S000002478
    Locus tag
    YDR071C
    See related
    AllianceGenome:SGD:S000002478; FungiDB:YDR071C; VEuPathDB:YDR071C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aralkylamine N-acetyltransferase activity and diamine N-acetyltransferase activity. Involved in chromatin organization. Located in cytoplasm. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PAA1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (588827..589402, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease DOA4 Neighboring gene Fmp16p Neighboring gene inositolphosphotransferase Neighboring gene Snf11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deciphering the melatonin metabolism in Saccharomyces cerevisiae by the bioconversion of related metabolites. Muñiz-Calvo S, et al. J Pineal Res, 2019 Apr. PMID 30633359
    2. Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87). Ganguly S, et al. J Biol Chem, 2001 Dec 14. PMID 11559708
    3. A yeast polyamine acetyltransferase. Liu B, et al. J Biol Chem, 2005 Apr 29. PMID 15723835
    4. Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Qin T, et al. Nucleic Acids Res, 2014 Oct. PMID 25063300, Free PMC Article
    5. Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements. Albuquerque CP, et al. PLoS Genet, 2013. PMID 23935535, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aralkylamine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aralkylamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diamine N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polyamine acetyltransferase
    NP_010356.1
    • Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      588827..589402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180379.1 → NP_010356.1  TPA: polyamine acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010356.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS57, Q12447
      UniProtKB/TrEMBL
      A6ZY36, B3LGJ9, B5VFW8, C7GVR5, C8Z4Y9, G2WAH5, N1P685
      Conserved Domains (1) summary
      COG0456
      Location:11 → 184
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12447.1

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