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    Zdhhc20 zinc finger, DHHC domain containing 20 [ Mus musculus (house mouse) ]

    Gene ID: 75965, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zdhhc20provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 20provided by MGI
    Primary source
    MGI:MGI:1923215
    See related
    Ensembl:ENSMUSG00000021969 AllianceGenome:MGI:1923215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HK11; 4930542A17Rik; 5033406L14Rik; B230110O18Rik
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Predicted to be involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation by host of viral process; and synaptic vesicle maturation. Predicted to be located in Golgi membrane and plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.8), limb E14.5 (RPKM 8.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc20 in Genome Data Viewer
    Location:
    14 C3; 14 30.51 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (58070159..58128288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57832702..57890831, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10829 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene predicted gene, 22738 Neighboring gene STARR-seq mESC enhancer starr_36817 Neighboring gene STARR-seq mESC enhancer starr_36818 Neighboring gene STARR-positive B cell enhancer ABC_E7320 Neighboring gene STARR-seq mESC enhancer starr_36822 Neighboring gene STARR-positive B cell enhancer ABC_E8996 Neighboring gene STARR-positive B cell enhancer ABC_E8560 Neighboring gene mitochondrial calcium uptake 2 Neighboring gene RIKEN cDNA 3110083C13 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis. Tomić G, et al. Cell Rep, 2024 May 28. PMID 38733589
    2. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-cysteine S-stearoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation by host of viral process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC20
    Names
    DHHC domain-containing cysteine-rich protein 20
    DHHC-20
    DHHC-containing protein 20
    acyltransferase ZDHHC20
    probable palmitoyltransferase ZDHHC20
    zinc finger DHHC domain-containing protein 20
    NP_001347026.1
    NP_001347027.1
    NP_083768.4
    XP_006519721.1
    XP_006519722.1
    XP_006519723.1
    XP_030103949.1
    XP_030103950.1
    XP_036014785.1
    XP_036014786.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360097.1 → NP_001347026.1  palmitoyltransferase ZDHHC20 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119813, AK017158, AK160951, AK163174, BC033914, BU609785
      Consensus CDS
      CCDS88676.1
      UniProtKB/Swiss-Prot
      Q3TDL1, Q5Y5T1, Q8VCL6, Q9D3Q8
      Related
      ENSMUSP00000153568.2, ENSMUST00000226057.2
      Conserved Domains (1) summary
      cl19890
      Location:16 → 316
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_001360098.1 → NP_001347027.1  palmitoyltransferase ZDHHC20 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119813, AK017158, AK160951, AK163174, BC033914
      Conserved Domains (1) summary
      cl19890
      Location:16 → 304
      zf-DHHC; DHHC palmitoyltransferase

    3. NM_029492.5 → NP_083768.4  palmitoyltransferase ZDHHC20 isoform 2

      See identical proteins and their annotated locations for NP_083768.4

      Status: VALIDATED

      Source sequence(s)
      AC119813, AK017158, AK160951, AK163174, BC033914
      Consensus CDS
      CCDS27162.1
      UniProtKB/Swiss-Prot
      Q5Y5T1
      Related
      ENSMUSP00000086900.4, ENSMUST00000089473.5
      Conserved Domains (1) summary
      cl19890
      Location:16 → 304
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      58070159..58128288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158893.1 → XP_036014786.1  palmitoyltransferase ZDHHC20 isoform X7

      Conserved Domains (1) summary
      cl19890
      Location:111 → 399
      DHHC; DHHC palmitoyltransferase

    2. XM_036158892.1 → XP_036014785.1  palmitoyltransferase ZDHHC20 isoform X6

      Conserved Domains (1) summary
      cl19890
      Location:111 → 411
      DHHC; DHHC palmitoyltransferase

    3. XM_006519659.4 → XP_006519722.1  palmitoyltransferase ZDHHC20 isoform X2

      Conserved Domains (1) summary
      cl19890
      Location:111 → 411
      DHHC; DHHC palmitoyltransferase

    4. XM_006519660.4 → XP_006519723.1  palmitoyltransferase ZDHHC20 isoform X3

      Conserved Domains (1) summary
      cl19890
      Location:111 → 411
      DHHC; DHHC palmitoyltransferase

    5. XM_006519658.5 → XP_006519721.1  palmitoyltransferase ZDHHC20 isoform X1

      See identical proteins and their annotated locations for XP_006519721.1

      Conserved Domains (1) summary
      cl19890
      Location:111 → 411
      DHHC; DHHC palmitoyltransferase

    6. XM_030248090.2 → XP_030103950.1  palmitoyltransferase ZDHHC20 isoform X5

      Conserved Domains (1) summary
      cl19890
      Location:111 → 399
      DHHC; DHHC palmitoyltransferase

    7. XM_030248089.1 → XP_030103949.1  palmitoyltransferase ZDHHC20 isoform X4

      Conserved Domains (1) summary
      COG5273
      Location:111 → 399
      COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]

    RNA

    1. XR_001781166.2 RNA Sequence

    2. XR_003950907.1 RNA Sequence

    3. XR_004938459.1 RNA Sequence

    4. XR_001781165.2 RNA Sequence

    5. XR_003950906.1 RNA Sequence

    6. XR_003950908.1 RNA Sequence

    7. XR_004938458.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5Y5T1.1 GenPept UniProtKB/Swiss-Prot:Q5Y5T1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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