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    Itih2 inter-alpha trypsin inhibitor, heavy chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 16425, updated on 3-Dec-2024

    Summary

    Official Symbol
    Itih2provided by MGI
    Official Full Name
    inter-alpha trypsin inhibitor, heavy chain 2provided by MGI
    Primary source
    MGI:MGI:96619
    See related
    Ensembl:ENSMUSG00000037254 AllianceGenome:MGI:96619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Intin2; Itih-2; ITI-HC2
    Summary
    Predicted to enable hyaluronic acid binding activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in germ cell of testis; gut; liver; and meninges. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 372.8), liver E14 (RPKM 211.7) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Itih2 in Genome Data Viewer
    Location:
    2 A1; 2 6.89 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10099408..10135492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10094591..10130683, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit gamma Neighboring gene predicted gene, 23608 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha-trypsin inhibitor, heavy chain 5 Neighboring gene STARR-seq mESC enhancer starr_03643 Neighboring gene predicted gene, 31496

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H2
    Names
    ITI heavy chain H2
    inter-alpha-inhibitor heavy chain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010582.4NP_034712.3  inter-alpha-trypsin inhibitor heavy chain H2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL772367
      Consensus CDS
      CCDS15677.2
      UniProtKB/Swiss-Prot
      A2AKU6, Q3UZM0, Q61703
      UniProtKB/TrEMBL
      Q8K016
      Related
      ENSMUSP00000046530.9, ENSMUST00000042290.14
      Conserved Domains (3) summary
      smart00609
      Location:56185
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:307488
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      pfam06668
      Location:735921
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      10099408..10135492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)