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    BOI2 Boi2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BOI2
    Official Full Name
    Boi2p
    Primary source
    SGD:S000000916
    Locus tag
    YER114C
    See related
    AllianceGenome:SGD:S000000916; FungiDB:YER114C; VEuPathDB:YER114C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BEB1
    Summary
    Enables phospholipid binding activity. Involved in several processes, including budding cell apical bud growth; septum digestion after cytokinesis; and vesicle fusion to plasma membrane. Located in cellular bud neck. Is active in cellular bud. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BOI2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (390590..393712, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene U6 snRNA complex subunit LSM4 Neighboring gene Tmn3p Neighboring gene Spr6p Neighboring gene SUMO-targeted ubiquitin ligase complex subunit SLX8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids. Hallett MA, et al. BMC Cell Biol, 2002 Jun 27. PMID 12097146, Free PMC Article
    2. Multiple proteins and phosphorylations regulate Saccharomyces cerevisiae Cdc24p localization. Cole KC, et al. FEBS Lett, 2009 Oct 20. PMID 19782078
    3. Yeast src homology region 3 domain-binding proteins involved in bud formation. Matsui Y, et al. J Cell Biol, 1996 May. PMID 8666671, Free PMC Article
    4. The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae. Liu Y, et al. Mol Microbiol, 2015 May. PMID 25708805
    5. Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in Yeast. Bender L, et al. J Cell Biol, 1996 May. PMID 8666672, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
      Title: Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
    2. The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
      Title: The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
    3. Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
      Title: Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in budding cell apical bud growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septum digestion after cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle fusion to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Boi2p
    NP_011039.1
    • Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      390590..393712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179004.1 → NP_011039.1  TPA: Boi2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011039.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM20, P39969
      UniProtKB/TrEMBL
      B5VHP0
      Conserved Domains (3) summary
      cd09535
      Location:264 → 328
      SAM_BOI-like_fungal; SAM domain of BOI-like fungal subfamily
      cd11886
      Location:47 → 101
      SH3_BOI; Src Homology 3 domain of fungal BOI-like proteins
      cd13316
      Location:770 → 886
      PH_Boi; Boi family Pleckstrin homology domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39969.1

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