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    Ssu72 Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 68991, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ssu72provided by MGI
    Official Full Name
    Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)provided by MGI
    Primary source
    MGI:MGI:1916241
    See related
    Ensembl:ENSMUSG00000029038 AllianceGenome:MGI:1916241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190002E22Rik; 1500011L16Rik; 2610101M12Rik
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and termination of RNA polymerase II transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in facial ganglion; trigeminal ganglion; and vestibulo-cochlear ganglion. Used to study liver disease. Orthologous to human SSU72 (SSU72 homolog, RNA polymerase II CTD phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 59.1), colon adult (RPKM 50.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ssu72 in Genome Data Viewer
    Location:
    4 E2; 4 87.07 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155789272..155818336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155704815..155733879)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 23 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene fibronectin type III domain containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E6297 Neighboring gene STARR-seq mESC enhancer starr_12272 Neighboring gene STARR-seq mESC enhancer starr_12273 Neighboring gene predicted gene, 22573 Neighboring gene RIKEN cDNA 1500002C15 gene Neighboring gene transmembrane protein 240 Neighboring gene ATPase family, AAA domain containing 3A Neighboring gene STARR-positive B cell enhancer ABC_E4739 Neighboring gene ATPase family, AAA domain containing 3A, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72
    Names
    CTD phosphatase SSU72
    NP_081175.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026899.3NP_081175.2  RNA polymerase II subunit A C-terminal domain phosphatase SSU72

      See identical proteins and their annotated locations for NP_081175.2

      Status: VALIDATED

      Source sequence(s)
      AK019168, BB867926, BU842478, BY237911
      Consensus CDS
      CCDS19036.1
      UniProtKB/Swiss-Prot
      Q3UF99, Q91YL1, Q9CY97, Q9DB51
      Related
      ENSMUSP00000030905.3, ENSMUST00000030905.9
      Conserved Domains (1) summary
      pfam04722
      Location:6194
      Ssu72; Ssu72-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155789272..155818336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)