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    Kin Kin17 DNA and RNA binding protein [ Mus musculus (house mouse) ]

    Gene ID: 16588, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kinprovided by MGI
    Official Full Name
    Kin17 DNA and RNA binding proteinprovided by MGI
    Primary source
    MGI:MGI:96676
    See related
    Ensembl:ENSMUSG00000037262 AllianceGenome:MGI:96676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kin17
    Summary
    Enables double-stranded DNA binding activity. Involved in DNA damage response and DNA replication. Located in nucleus. Is expressed in several structures, including branchial arch; cerebral cortex; inner ear; limb; and midgut. Orthologous to human KIN (Kin17 DNA and RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 7.3) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kin in Genome Data Viewer
    Location:
    2 A1; 2 6.88 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10085397..10097512)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10080551..10092701)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene predicted gene, 54137 Neighboring gene STARR-positive B cell enhancer ABC_E11119 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene predicted gene, 23608 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 2 Neighboring gene inter-alpha-trypsin inhibitor, heavy chain 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA/RNA-binding protein KIN17
    Names
    KIN, antigenic determinant of recA protein homolog
    antigenic determinant of rec-A protein
    binding to curved DNA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420343.1NP_001407272.1  DNA/RNA-binding protein KIN17 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772367
    2. NM_001420344.1NP_001407273.1  DNA/RNA-binding protein KIN17 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772367
    3. NM_025280.3NP_079556.1  DNA/RNA-binding protein KIN17 isoform 1

      See identical proteins and their annotated locations for NP_079556.1

      Status: VALIDATED

      Source sequence(s)
      AL772367
      Consensus CDS
      CCDS15676.1
      UniProtKB/Swiss-Prot
      Q8K339, Q9CV58
      Related
      ENSMUSP00000043614.8, ENSMUST00000042512.8
      Conserved Domains (4) summary
      smart00451
      Location:2554
      ZnF_U1; U1-like zinc finger
      cd13155
      Location:337390
      KOW_KIN17; KOW_Kin17 is a RNA-binding motif
      sd00020
      Location:2850
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam10357
      Location:55177
      Kin17_mid; Domain of Kin17 curved DNA-binding protein

    RNA

    1. NR_185163.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772367

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      10085397..10097512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)