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    Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 73694, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufaf7provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase complex assembly factor 7provided by MGI
    Primary source
    MGI:MGI:1920944
    See related
    Ensembl:ENSMUSG00000024082 AllianceGenome:MGI:1920944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRO1853; 2410091C18Rik
    Summary
    Predicted to enable enzyme binding activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine methylation, to symmetrical-dimethyl arginine. Located in mitochondrion. Is expressed in brain. Orthologous to human NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.7), cortex adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ndufaf7 in Genome Data Viewer
    Location:
    17 E3; 17 49.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79244535..79255481)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78937106..78948052)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26637 Neighboring gene sulfotransferase family, cytosolic, 6B, member 1 Neighboring gene STARR-seq mESC enhancer starr_43273 Neighboring gene STARR-positive B cell enhancer ABC_E8698 Neighboring gene CCAAT/enhancer binding protein zeta, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5629 Neighboring gene CCAAT/enhancer binding protein zeta Neighboring gene protein kinase D3 Neighboring gene predicted gene, 41622 Neighboring gene STARR-seq mESC enhancer starr_43275 Neighboring gene glutaminyl-peptide cyclotransferase (glutaminyl cyclase)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC117993

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AQ104 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K37 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R17 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R2 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R26 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3R8 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K12 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4R3 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-arginine omega-N symmetric methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-arginine omega-N symmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine omega-N symmetric methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein arginine methyltransferase NDUFAF7, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 7
    NADH dehydrogenase [ubiquinone] complex I, assembly factor 7
    protein midA homolog, mitochondrial
    NP_082887.2
    XP_006525058.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028611.3NP_082887.2  protein arginine methyltransferase NDUFAF7, mitochondrial precursor

      See identical proteins and their annotated locations for NP_082887.2

      Status: VALIDATED

      Source sequence(s)
      AC154274, AK010752, CF617214, CX236822
      Consensus CDS
      CCDS28982.1
      UniProtKB/Swiss-Prot
      E9QLM6, Q8C1X3, Q9CWG8
      Related
      ENSMUSP00000024887.5, ENSMUST00000024887.6
      Conserved Domains (2) summary
      COG1565
      Location:46402
      MidA; SAM-dependent methyltransferase, MidA family [General function prediction only]
      pfam02636
      Location:95349
      Methyltransf_28; Putative S-adenosyl-L-methionine-dependent methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      79244535..79255481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524995.2XP_006525058.1  protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:46354
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_385374.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144760.1: Suppressed sequence

      Description
      NM_144760.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.