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    Prkar2b protein kinase, cAMP dependent regulatory, type II beta [ Mus musculus (house mouse) ]

    Gene ID: 19088, updated on 3-Dec-2024

    Summary

    Official Symbol
    Prkar2bprovided by MGI
    Official Full Name
    protein kinase, cAMP dependent regulatory, type II betaprovided by MGI
    Primary source
    MGI:MGI:97760
    See related
    Ensembl:ENSMUSG00000002997 AllianceGenome:MGI:97760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkarb2; RII(beta); PKARIIbeta
    Summary
    Enables cAMP-dependent protein kinase regulator activity and protein kinase binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within fatty acid metabolic process and learning. Located in ciliary base; cytoplasm; and dendrite. Part of cAMP-dependent protein kinase complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; liver; primary palate; retina; and testis. Orthologous to human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 61.4), adrenal adult (RPKM 55.1) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prkar2b in Genome Data Viewer
    Location:
    12 A3; 12 13.74 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (32008468..32111639, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31958450..32061648, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene predicted gene, 35666 Neighboring gene STARR-positive B cell enhancer ABC_E79 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32658358-32658559 Neighboring gene high mobility group box transcription factor 1 Neighboring gene predicted gene, 53716 Neighboring gene STARR-positive B cell enhancer ABC_E4024 Neighboring gene STARR-seq mESC enhancer starr_31869 Neighboring gene predicted gene, 51992 Neighboring gene predicted gene, 33111

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A catalytic subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A catalytic subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cAMP-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cAMP-dependent protein kinase type II-beta regulatory subunit
    NP_001351336.1
    NP_001351337.1
    NP_001409252.1
    NP_035288.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364407.1NP_001351336.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT010463
      Consensus CDS
      CCDS25869.1
      UniProtKB/Swiss-Prot
      B1B199, P31324, Q3UTZ1, Q80ZM4, Q8BRZ7
      Related
      ENSMUSP00000003079.6, ENSMUST00000003079.12
      Conserved Domains (2) summary
      cd12104
      Location:343
      DD_RIIbeta_PKA; Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:274394
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    2. NM_001364408.1NP_001351337.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010463
      Consensus CDS
      CCDS88324.1
      UniProtKB/TrEMBL
      H3BK84, Q3V2X9
      Related
      ENSMUSP00000135290.2, ENSMUST00000146865.2
      Conserved Domains (1) summary
      cd00038
      Location:114234
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    3. NM_001422323.1NP_001409252.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010463
      UniProtKB/TrEMBL
      H3BK84, Q3V2X9
    4. NM_011158.4NP_035288.2  cAMP-dependent protein kinase type II-beta regulatory subunit isoform 1

      See identical proteins and their annotated locations for NP_035288.2

      Status: VALIDATED

      Source sequence(s)
      AK135621, AK138963, CJ238090, CT010463
      Consensus CDS
      CCDS25869.1
      UniProtKB/Swiss-Prot
      B1B199, P31324, Q3UTZ1, Q80ZM4, Q8BRZ7
      Related
      ENSMUSP00000039797.10, ENSMUST00000036497.16
      Conserved Domains (2) summary
      cd12104
      Location:343
      DD_RIIbeta_PKA; Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:274394
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      32008468..32111639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)