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    KEG1 Keg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KEG1
    Official Full Name
    Keg1p
    Primary source
    SGD:S000001938
    Locus tag
    YFR042W
    See related
    AllianceGenome:SGD:S000001938; FungiDB:YFR042W; VEuPathDB:YFR042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in (1->6)-beta-D-glucan biosynthetic process and chromosome organization. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KEG1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (238458..239060)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Sap155p Neighboring gene Erj5p Neighboring gene Irc6p Neighboring gene metallodipeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae. Nakamata K, et al. J Biol Chem, 2007 Nov 23. PMID 17893149
    2. Action of multiple endoplasmic reticulum chaperon-like proteins is required for proper folding and polarized localization of Kre6 protein essential in yeast cell wall β-1,6-glucan synthesis. Kurita T, et al. J Biol Chem, 2012 May 18. PMID 22447934, Free PMC Article
    3. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Ben-Aroya S, et al. Mol Cell, 2008 Apr 25. PMID 18439903, Free PMC Article
    4. Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Murakami Y, et al. Nat Genet, 1995 Jul. PMID 7670463
    5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Keg1 and Kre6 have a cooperative role in beta-1,6-glucan synthesis in S. cerevisiae.
      Title: KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->6)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Keg1p
    NP_116700.1
    • Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      238458..239060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180007.1 → NP_116700.1  TPA: Keg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116700.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5A8M3, D6VTS5, P43614
      UniProtKB/TrEMBL
      G2WDI3, N1P2Z5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43614.1

    Gene LinkOut

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