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    Mettl1 methyltransferase 1, tRNA methylguanosine [ Mus musculus (house mouse) ]

    Gene ID: 17299, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mettl1provided by MGI
    Official Full Name
    methyltransferase 1, tRNA methylguanosineprovided by MGI
    Primary source
    MGI:MGI:1339986
    See related
    Ensembl:ENSMUSG00000006732 AllianceGenome:MGI:1339986
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810012D02Rik
    Summary
    Predicted to enable internal mRNA (guanine-N7-)-methyltransferase activity and tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation and tRNA stabilization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.7), placenta adult (RPKM 9.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mettl1 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126877287..126882234)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127041549..127046365)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables internal mRNA (guanine-N7-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables internal mRNA (guanine-N7-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA (guanine(46)-N7)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA (guanine(46)-N7)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA (guanine-N7)-methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA (guanine-N7)-methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA (guanine-N7)-methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of tRNA (m7G46) methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of tRNA (m7G46) methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of tRNA methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tRNA (guanine-N(7)-)-methyltransferase
    Names
    mRNA (guanine-N(7)-)-methyltransferase
    methyltransferase like 1
    miRNA (guanine-N(7)-)-methyltransferase
    NP_034922.1
    XP_006513375.1
    XP_006513376.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010792.1NP_034922.1  tRNA (guanine-N(7)-)-methyltransferase

      See identical proteins and their annotated locations for NP_034922.1

      Status: PROVISIONAL

      Source sequence(s)
      AB023619
      Consensus CDS
      CCDS24223.1
      UniProtKB/Swiss-Prot
      Q3TU83, Q921G5, Q9Z120
      Related
      ENSMUSP00000006915.8, ENSMUST00000006915.14
      Conserved Domains (1) summary
      pfam02390
      Location:71248
      Methyltransf_4; Putative methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      126877287..126882234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513312.3XP_006513375.1  tRNA (guanine-N(7)-)-methyltransferase isoform X1

      Conserved Domains (1) summary
      pfam02390
      Location:118295
      Methyltransf_4; Putative methyltransferase
    2. XM_006513313.4XP_006513376.1  tRNA (guanine-N(7)-)-methyltransferase isoform X2

      UniProtKB/TrEMBL
      D3Z7D2
      Related
      ENSMUSP00000113030.2, ENSMUST00000120542.8
      Conserved Domains (1) summary
      cl17173
      Location:118232
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...