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    Sec23ip Sec23 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 207352, updated on 3-Dec-2024

    Summary

    Official Symbol
    Sec23ipprovided by MGI
    Official Full Name
    Sec23 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2450915
    See related
    Ensembl:ENSMUSG00000055319 AllianceGenome:MGI:2450915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p125; D7Ertd373e
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within acrosome assembly and single fertilization. Located in cis-Golgi network; endoplasmic reticulum exit site; and perinuclear endoplasmic reticulum. Orthologous to human SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.2), thymus adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sec23ip in Genome Data Viewer
    Location:
    7 F3; 7 70.51 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128346667..128386560)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128744862..128784836)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene minichromosome maintenance complex binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3757 Neighboring gene STARR-seq mESC enhancer starr_20212 Neighboring gene STARR-seq mESC enhancer starr_20213 Neighboring gene STARR-seq mESC enhancer starr_20214 Neighboring gene predicted gene, 39093 Neighboring gene predicted gene, 32884 Neighboring gene STARR-seq mESC enhancer starr_20215

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ER to Golgi transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029982.3NP_001025153.2  SEC23-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001025153.2

      Status: VALIDATED

      Source sequence(s)
      AC136741
      Consensus CDS
      CCDS21900.1
      UniProtKB/TrEMBL
      G3X928, Q4G0C0
      Related
      ENSMUSP00000035610.9, ENSMUST00000042942.10
      Conserved Domains (3) summary
      smart00454
      Location:649700
      SAM; Sterile alpha motif
      pfam02862
      Location:780986
      DDHD; DDHD domain
      cl15755
      Location:634702
      SAM_superfamily; SAM (Sterile alpha motif )
    2. NM_001420513.1NP_001407442.1  SEC23-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC136741
      UniProtKB/TrEMBL
      Q4G0C0
    3. NM_001420514.1NP_001407443.1  SEC23-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC136741
      UniProtKB/TrEMBL
      A0AUN0

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      128346667..128386560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)