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    Proca1 protein interacting with cyclin A1 [ Mus musculus (house mouse) ]

    Gene ID: 216974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Proca1provided by MGI
    Official Full Name
    protein interacting with cyclin A1provided by MGI
    Primary source
    MGI:MGI:1918274
    See related
    Ensembl:ENSMUSG00000044122 AllianceGenome:MGI:1918274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933404M19Rik
    Summary
    Predicted to enable cyclin binding activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial protein catabolic process. Predicted to be located in mitochondrion. Orthologous to human PROCA1 (protein interacting with cyclin A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 38.8) and subcutaneous fat pad adult (RPKM 1.4) See more
    Orthologs
    human all
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    Genomic context

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    See Proca1 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78083086..78096589)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78192677..78205763)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5250 Neighboring gene ribosomal protein L23A Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene Rab34 Hedgehog-responsive enhancer Neighboring gene RAB34, member RAS oncogene family Neighboring gene SPT6, histone chaperone and transcription elongation factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78029402-78029555 Neighboring gene STARR-seq mESC enhancer starr_30092 Neighboring gene stromal cell derived factor 2 Neighboring gene small nuclear ribonucleoprotein N pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein PROCA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045516.2 → NP_001038981.2  protein PROCA1 isoform 2

      See identical proteins and their annotated locations for NP_001038981.2

      Status: VALIDATED

      Source sequence(s)
      AK160258, AL591070, BY648103
      Consensus CDS
      CCDS36238.1
      UniProtKB/TrEMBL
      B0QZF6
      Related
      ENSMUSP00000086022.3, ENSMUST00000078099.4
      Conserved Domains (1) summary
      cl05417
      Location:1 → 36
      PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    2. NM_001368876.1 → NP_001355805.1  protein PROCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591070
      Consensus CDS
      CCDS88201.1
      UniProtKB/Swiss-Prot
      B0QZF7
      Related
      ENSMUSP00000103953.3, ENSMUST00000108317.3
      Conserved Domains (1) summary
      cd04705
      Location:30 → 123
      PLA2_group_III_like; A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78083086..78096589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245840.2 → XP_030101700.1  protein PROCA1 isoform X1

      UniProtKB/TrEMBL
      B0QZF6
      Conserved Domains (1) summary
      cl05417
      Location:1 → 36
      PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    2. XM_036156580.1 → XP_036012473.1  protein PROCA1 isoform X1

      UniProtKB/TrEMBL
      B0QZF6
      Conserved Domains (1) summary
      cl05417
      Location:1 → 36
      PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    3. XM_036156581.1 → XP_036012474.1  protein PROCA1 isoform X1

      UniProtKB/TrEMBL
      B0QZF6
      Conserved Domains (1) summary
      cl05417
      Location:1 → 36
      PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0QZF7.1 GenPept UniProtKB/Swiss-Prot:B0QZF7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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