Kif27 kinesin family member 27 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif27provided by MGI
Official Full Name: kinesin family member 27provided by MGI
Primary source: MGI:MGI:1922300
See related: Ensembl:ENSMUSG00000060176 AllianceGenome:MGI:1922300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930517I18Rik
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in cilium assembly. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and ventricular system development. Located in cilium. Is expressed in several structures, including choroid plexus; floor plate; genitourinary system; liver; and spleen. Used to study hydrocephalus. Orthologous to human KIF27 (kinesin family member 27). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 15.0) and CNS E18 (RPKM 0.7) See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.99 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (58432541..58512559, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (58284727..58364745, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slow processive KIF27 behavior arises from a slow adenosine triphosphatase rate and a high affinity for both adenosine triphosphate and microtubules.
Title: Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.
Congenital hydrocephalus, suppurative rhinosinusitis and otitis media in Kif27 null mice is indicative of primary ciliary dyskinesis
Title: Congenital hydrocephalus in genetically engineered mice.
Kif27 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Mit279 (e-PCR), detects polymorphism
- UniSTS:127097

NoName (e-PCR)
- UniSTS:237034

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF27

Names: kinesin-related protein KIF27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360894.1 → NP_001347823.1 kinesin-like protein KIF27 isoform 2

Status: VALIDATED

Source sequence(s)

AC154437, AC163038, AW494673, BC116646

Conserved Domains (1) summary

COG1196
Location:258 → 633

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_175214.4 → NP_780423.2 kinesin-like protein KIF27 isoform 1

See identical proteins and their annotated locations for NP_780423.2

Status: VALIDATED

Source sequence(s)

AC154437, AC163038, AW494673, BK001056

Consensus CDS

CCDS26570.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Related

ENSMUSP00000043304.6, ENSMUST00000043605.6

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

58432541..58512559 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517436.4 → XP_006517499.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517499.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006517433.5 → XP_006517496.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517496.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_011244580.4 → XP_011242882.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_011242882.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006517435.4 → XP_006517498.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517498.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_036158200.1 → XP_036014093.1 kinesin-like protein KIF27 isoform X5

Conserved Domains (1) summary

COG1196
Location:258 → 633

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006517429.4 → XP_006517492.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517492.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_011244579.3 → XP_011242881.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_011242881.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_017315620.2 → XP_017171109.1 kinesin-like protein KIF27 isoform X1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_017315619.2 → XP_017171108.1 kinesin-like protein KIF27 isoform X1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006517431.3 → XP_006517494.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517494.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_030247439.1 → XP_030103299.1 kinesin-like protein KIF27 isoform X5

Conserved Domains (1) summary

COG1196
Location:258 → 633

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006517426.3 → XP_006517489.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517489.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Related

ENSMUSP00000153598.2, ENSMUST00000225388.2

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006517427.3 → XP_006517490.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517490.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_006517434.3 → XP_006517497.1 kinesin-like protein KIF27 isoform X1

See identical proteins and their annotated locations for XP_006517497.1

UniProtKB/Swiss-Prot

Q14AX5, Q7M6Z4, Q8BMB9

Conserved Domains (2) summary

COG1196
Location:721 → 1096

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_017315623.1 → XP_017171112.1 kinesin-like protein KIF27 isoform X4

Conserved Domains (2) summary

COG1196
Location:673 → 1048

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_017315621.2 → XP_017171110.1 kinesin-like protein KIF27 isoform X2

Conserved Domains (2) summary

COG1196
Location:721 → 1077

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
XM_017315622.2 → XP_017171111.1 kinesin-like protein KIF27 isoform X3

Conserved Domains (3) summary

TIGR00618
Location:332 → 967

sbcc; exonuclease SbcC

COG0419
Location:678 → 1203

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01372
Location:4 → 342

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily