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    Taf5l TATA-box binding protein associated factor 5 like [ Mus musculus (house mouse) ]

    Gene ID: 102162, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf5lprovided by MGI
    Official Full Name
    TATA-box binding protein associated factor 5 likeprovided by MGI
    Primary source
    MGI:MGI:1919039
    See related
    Ensembl:ENSMUSG00000038697 AllianceGenome:MGI:1919039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110005N04Rik
    Summary
    Predicted to enable transcription coactivator activity. Involved in regulation of DNA-templated transcription and regulation of somatic stem cell population maintenance. Located in nucleus. Is expressed in genitourinary system and tail. Orthologous to human TAF5L (TATA-box binding protein associated factor 5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.0), ovary adult (RPKM 20.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf5l in Genome Data Viewer
    Location:
    8 E2; 8 72.31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124723049..124748136, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123996310..124021397, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29773 Neighboring gene nucleoporin 133 Neighboring gene ATP-binding cassette, sub-family B member 10 Neighboring gene predicted gene, 53469 Neighboring gene STARR-seq mESC enhancer starr_22990 Neighboring gene STARR-seq mESC enhancer starr_22991 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 1967 Neighboring gene URB2 ribosome biogenesis 2 homolog (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:126581223-126581424 Neighboring gene predicted gene, 29897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Seruggia D, et al. Mol Cell, 2019 Jun 20. PMID 31005419, Free PMC Article
    2. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. Schiltz RL, et al. J Biol Chem, 1999 Jan 15. PMID 9880483
    3. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077
    4. Histone-like TAFs within the PCAF histone acetylase complex. Ogryzko VV, et al. Cell, 1998 Jul 10. PMID 9674425
    5. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Brand M, et al. EMBO J, 2001 Jun 15. PMID 11406595, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network.
      Title: TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of somatic stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFTC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
    Names
    PAF65-beta
    PCAF-associated factor 65 beta
    TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357315.1 → NP_001344244.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

      Status: VALIDATED

      Source sequence(s)
      AC139575, AI849020, AK033477
      Consensus CDS
      CCDS22767.1
      UniProtKB/Swiss-Prot
      Q8BTL5, Q91WQ5
      Related
      ENSMUSP00000090726.6, ENSMUST00000093039.6
      Conserved Domains (3) summary
      cd08044
      Location:67 → 201
      TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
      cd00200
      Location:276 → 581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:345 → 381
      7WD40; WD40 repeat [structural motif]

    2. NM_133966.3 → NP_598727.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

      See identical proteins and their annotated locations for NP_598727.1

      Status: VALIDATED

      Source sequence(s)
      AI849020, AK033477, AK089463, BB852568
      Consensus CDS
      CCDS22767.1
      UniProtKB/Swiss-Prot
      Q8BTL5, Q91WQ5
      Related
      ENSMUSP00000128710.2, ENSMUST00000165628.9
      Conserved Domains (3) summary
      cd08044
      Location:67 → 201
      TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
      cd00200
      Location:276 → 581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:345 → 381
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124723049..124748136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WQ5.1 GenPept UniProtKB/Swiss-Prot:Q91WQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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