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    BUD2 GTPase-activating protein BUD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BUD2
    Official Full Name
    GTPase-activating protein BUD2
    Primary source
    SGD:S000001575
    Locus tag
    YKL092C
    See related
    AllianceGenome:SGD:S000001575; FungiDB:YKL092C; VEuPathDB:YKL092C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLA2; ERC25
    Summary
    Enables GTPase activator activity. Involved in cellular bud site selection; invasive growth in response to glucose limitation; and mitotic spindle orientation checkpoint signaling. Located in cellular bud neck and incipient cellular bud site. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 5; lung cancer; prostate cancer; and stomach cancer. Orthologous to several human genes including DAB2IP (DAB2 interacting protein); RASAL2 (RAS protein activator like 2); and RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BUD2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (266145..269459, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene acylglycerol lipase Neighboring gene Mbr1p Neighboring gene phosphatidylinositol/phosphatidylcholine-binding protein Neighboring gene Cue2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The morphology of Saccharomyces cerevisiae colonies is affected by cell adhesion and the budding pattern. Vopálenská I, et al. Res Microbiol, 2005 Nov. PMID 16081250
    2. Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site. Park HO, et al. Genes Dev, 1999 Aug 1. PMID 10444589, Free PMC Article
    3. A localized GTPase exchange factor, Bud5, determines the orientation of division axes in yeast. Marston AL, et al. Curr Biol, 2001 May 15. PMID 11378394
    4. A novel role for the GTPase-activating protein Bud2 in the spindle position checkpoint. Nelson SA, et al. PLoS One, 2012. PMID 22558355, Free PMC Article
    5. BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Park HO, et al. Nature, 1993 Sep 16. PMID 8371782

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle orientation checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    GTPase-activating protein BUD2
    NP_012831.1
    • GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      266145..269459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179658.1 → NP_012831.1  TPA: GTPase-activating protein BUD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012831.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXJ6, P33314
      UniProtKB/TrEMBL
      A6ZZM5, G2WHU1, N1P7R7
      Conserved Domains (2) summary
      cd00030
      Location:337 → 444
      C2; C2 domain
      cd05137
      Location:460 → 819
      RasGAP_CLA2_BUD2; Ras-GTPase Activating Domain of CLA2/BUD2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33314.2

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