HYM1 Hym1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: HYM1
Official Full Name: Hym1p
Primary source: SGD:S000001672
Locus tag: YKL189W
See related: AllianceGenome:SGD:S000001672; FungiDB:YKL189W; VEuPathDB:YKL189W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable protein serine/threonine kinase activator activity. Involved in budding cell apical bud growth; regulation of DNA-templated transcription; and septum digestion after cytokinesis. Located in cellular bud; incipient cellular bud site; and mating projection tip. Used to study cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including CAB39L (calcium binding protein 39 like). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Kic1 is allosterically activated by Hym1.
Title: Cell cycle regulated interaction of a yeast Hippo kinase and its activator MO25/Hym1.
Hym1p requires Dcr2p(a phosphatase)and Gid8p (involved in protein degradation) to promote the transition from the G1 to S phase of the cell cycle
Title: Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.
Hym1p has a regulatory role in cell cycle progression
Title: Hym1p affects cell cycle progression in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in budding cell apical bud growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in budding cell apical bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septum digestion after cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed

NP_012732.1

Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis; interacts with Sog2p; allosterically activates Kic1p; localizes to sites of polarized growth during budding and during the mating response