U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NRXN3 neurexin 3 [ Homo sapiens (human) ]

    Gene ID: 9369, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NRXN3provided by HGNC
    Official Full Name
    neurexin 3provided by HGNC
    Primary source
    HGNC:HGNC:8010
    See related
    Ensembl:ENSG00000021645 MIM:600567; AllianceGenome:HGNC:8010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf60
    Summary
    This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in brain (RPKM 7.1), adrenal (RPKM 1.0) and 11 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NRXN3 in Genome Data Viewer
    Location:
    14q24.3-q31.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (78170373..79868291)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (72379419..74078363)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (78636716..80334634)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:78446972-78447490 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:78459957-78460576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:78479894-78480577 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:78495292-78496095 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:78496096-78496898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:78498735-78499236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:78556875-78557374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:78563399-78563899 Neighboring gene tRNA suppressor (anticodon CTA) 3-1 Neighboring gene frataxin pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 388 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:78793548-78794747 Neighboring gene ribosomal protein S26 pseudogene 48 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8817 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36905 Neighboring gene MPRA-validated peak2214 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5982 Neighboring gene Sharpr-MPRA regulatory region 7209 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36943 Neighboring gene uncharacterized LOC105370589 Neighboring gene MPRA-validated peak2216 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:79358917-79359500 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:79359501-79360083 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:79400229-79400386 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:79451802-79452322 Neighboring gene uncharacterized LOC124903353 Neighboring gene uncharacterized LOC105370588 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:79557624-79558323 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:79625382-79626581 Neighboring gene uncharacterized LOC124903352 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37191 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37197 Neighboring gene uncharacterized LOC105370586 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37233 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37268 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:79800513-79801035 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37315 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:79840048-79840650 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:79840651-79841251 Neighboring gene NANOG hESC enhancer GRCh37_chr14:79844983-79845538 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:79844122-79844915 Neighboring gene NANOG hESC enhancer GRCh37_chr14:79982121-79982761 Neighboring gene uncharacterized LOC124903354 Neighboring gene uncharacterized LOC105370583 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37450 Neighboring gene VISTA enhancer hs1369 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:80097297-80097798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:80097799-80098298 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37460 Neighboring gene NANOG hESC enhancer GRCh37_chr14:80146690-80147283 Neighboring gene NANOG hESC enhancer GRCh37_chr14:80287015-80287781 Neighboring gene uncharacterized LOC105370582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_37584 Neighboring gene uncharacterized LOC107984630 Neighboring gene uncharacterized LOC112267892

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk. Kusinska R, et al. Mol Biol Rep, 2012 Mar. PMID 21688152, Free PMC Article
    2. Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms. Güleç G, et al. Turk Psikiyatri Derg, 2021 Fall. PMID 34750790
    3. Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms. Güleç G, et al. Turk Psikiyatri Derg, 2021 Fall. PMID 34647286
    4. Associations among types of impulsivity, substance use problems and neurexin-3 polymorphisms. Stoltenberg SF, et al. Drug Alcohol Depend, 2011 Dec 15. PMID 21676558, Free PMC Article
    5. Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3). Occhi G, et al. Biochem Biophys Res Commun, 2002 Oct 18. PMID 12379233

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.", trans "Nikotin Kullanim Bozuklugunun Neurexin 3 Gen Polimorfizmi ile Iliskisi.
      Title: Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.
    2. Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.", trans "Nikotin Kullanim Bozuklugunun Neurexin 3 Gen Polimorfizmi ile Iliskisi.
      Title: Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.
    3. Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.
      Title: Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.
    4. Modeling a Neurexin-3alpha Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.
      Title: Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.
    5. Study found that expression and ratio of transmembrane and soluble NRXN3 isoforms were reduced in Alzheimer disease (AD) postmortem brains and inversely correlated with inflammasome component NLRP3 in AD brain regions.
      Title: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease.
    6. The neurexins are a family of synaptic adhesion proteins encoded by paralogous genes that play key roles in synaptic function.
      Title: Neurexin gene family variants as risk factors for autism spectrum disorder.
    7. NRXN2 may play a part in early cortical synaptogenesis, but NRXNs could have diverse roles in development including axon guidance, and intercellular communication between proliferating cells and/or migrating neurons.
      Title: Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.
    8. The rare variants in NRXN3 were significantly associated with smoking status.
      Title: The contribution of rare and common variants in 30 genes to risk nicotine dependence.
    9. This study confirmed the genetic heterogeneity of cluster headache, suggesting that a novel rearrangement involving NRXN3 gene might be related to cluster headache in a subset of cases
      Title: Molecular analysis of cluster headache.
    10. The study showed that markers rs2217887 (NRXN3) showed weak associations.
      Title: Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study on obesity and obesity-related traits.
    EBI GWAS Catalog
    Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
    EBI GWAS Catalog
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Common genetic variation and performance on standardized cognitive tests.
    EBI GWAS Catalog
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
    EBI GWAS Catalog
    Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NRXN3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ38928, FLJ44845, KIAA0743, MGC176711

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuroligin family protein binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		  
    enables transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    		  
    involved_in learning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in social behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vocalization behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of trans-synaptic protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    neurexin 3
    Names
    neurexin III
    neurexin-3-alpha

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052991.1 RefSeqGene

      Range
      5001..1702919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001105250.3 → NP_001098720.1  neurexin 3 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001098720.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.
      Source sequence(s)
      AF123462, BC150194, DA243312
      Consensus CDS
      CCDS45145.1
      UniProtKB/Swiss-Prot
      Q9HDB5
      Related
      ENSP00000394426.2, ENST00000428277.6
      Conserved Domains (2) summary
      cd00110
      Location:86 → 265
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:385 → 420
      Syndecan; Syndecan domain

    2. NM_001272020.2 → NP_001258949.1  neurexin 3 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001258949.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.
      Source sequence(s)
      AF123462, AK056530, BC150194
      Consensus CDS
      CCDS61515.1
      UniProtKB/Swiss-Prot
      A5PKW8, A8MPU5, B3KPM7, Q6NUR0, Q8IUD8, Q9HDB5
      UniProtKB/TrEMBL
      A0A7I2V2B1
      Related
      ENSP00000451672.1, ENST00000557594.5
      Conserved Domains (2) summary
      cd00110
      Location:86 → 235
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:563 → 598
      Syndecan; Syndecan domain

    3. NM_001330195.2 → NP_001317124.1  neurexin 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7)
      Source sequence(s)
      AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
      Consensus CDS
      CCDS81831.1
      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      UniProtKB/TrEMBL
      A0A0A0MR89
      Related
      ENSP00000338349.7, ENST00000335750.7
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1497 → 1532
      Syndecan; Syndecan domain
      pfam02210
      Location:899 → 1027
      Laminin_G_2; Laminin G domain

    4. NM_001366425.1 → NP_001353354.1  neurexin 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1467 → 1502
      Syndecan; Syndecan domain
      pfam02210
      Location:899 → 1027
      Laminin_G_2; Laminin G domain

    5. NM_001366426.1 → NP_001353355.1  neurexin 3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462
      Consensus CDS
      CCDS91913.1
      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      UniProtKB/TrEMBL
      A0A0U1RQC5
      Related
      ENSP00000488920.2, ENST00000634499.2
      Conserved Domains (6) summary
      smart00282
      Location:286 → 417
      LamG; Laminin G domain
      cd00054
      Location:651 → 684
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1394 → 1429
      Syndecan; Syndecan domain
      pfam02210
      Location:903 → 1031
      Laminin_G_2; Laminin G domain

    6. NM_004796.6 → NP_004787.2  neurexin 3 isoform 1

      See identical proteins and their annotated locations for NP_004787.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC007056, AC026888, AF123462, BC150194, BC152457, DA213090
      Consensus CDS
      CCDS9870.1
      UniProtKB/Swiss-Prot
      Q9HDB5, Q9Y4C0
      Related
      ENSP00000451648.1, ENST00000554719.5
      Conserved Domains (5) summary
      smart00282
      Location:97 → 246
      LamG; Laminin G domain
      cd00054
      Location:274 → 307
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:718 → 867
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:987 → 1022
      Syndecan; Syndecan domain
      pfam02210
      Location:526 → 654
      Laminin_G_2; Laminin G domain

    7. NM_138970.5 → NP_620426.2  neurexin 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_620426.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform.
      Source sequence(s)
      AF123462, AK056530, BC059368, BC150194
      Consensus CDS
      CCDS9871.1
      UniProtKB/Swiss-Prot
      Q9HDB5
      Related
      ENSP00000281127.7, ENST00000281127.11
      Conserved Domains (2) summary
      cd00110
      Location:86 → 235
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:358 → 393
      Syndecan; Syndecan domain

    RNA

    1. NR_073546.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains multiple differences in its 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF123462, AJ493127, AK056530, BC150194

    2. NR_073547.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains multiple differences in its 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF123462, AJ316284, BC150194, DA083962

    3. NR_158973.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

    4. NR_158974.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

    5. NR_158975.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007955, AC008045, AC008056, AC009396, AC012099, AC026888, AF099810, AF123462

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      78170373..79868291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537363.2 → XP_011535665.1  neurexin 3 isoform X1

      See identical proteins and their annotated locations for XP_011535665.1

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 425
      LamG; Laminin G domain
      cd00054
      Location:659 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1613 → 1648
      Syndecan; Syndecan domain
      pfam02210
      Location:911 → 1039
      Laminin_G_2; Laminin G domain

    2. XM_011537368.2 → XP_011535670.1  neurexin 3 isoform X15

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 425
      LamG; Laminin G domain
      cd00054
      Location:659 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1512 → 1547
      Syndecan; Syndecan domain
      pfam02210
      Location:911 → 1039
      Laminin_G_2; Laminin G domain

    3. XM_011537371.2 → XP_011535673.1  neurexin 3 isoform X27

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 425
      LamG; Laminin G domain
      cd00054
      Location:659 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1405 → 1440
      Syndecan; Syndecan domain
      pfam02210
      Location:911 → 1039
      Laminin_G_2; Laminin G domain

    4. XM_005268218.4 → XP_005268275.1  neurexin 3 isoform X2

      See identical proteins and their annotated locations for XP_005268275.1

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 425
      LamG; Laminin G domain
      cd00054
      Location:659 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1610 → 1645
      Syndecan; Syndecan domain
      pfam02210
      Location:911 → 1039
      Laminin_G_2; Laminin G domain

    5. XM_011537369.2 → XP_011535671.1  neurexin 3 isoform X16

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 425
      LamG; Laminin G domain
      cd00054
      Location:659 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1509 → 1544
      Syndecan; Syndecan domain
      pfam02210
      Location:911 → 1039
      Laminin_G_2; Laminin G domain

    6. XM_011537372.2 → XP_011535674.1  neurexin 3 isoform X28

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 425
      LamG; Laminin G domain
      cd00054
      Location:659 → 692
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1402 → 1437
      Syndecan; Syndecan domain
      pfam02210
      Location:911 → 1039
      Laminin_G_2; Laminin G domain

    7. XM_017021799.3 → XP_016877288.1  neurexin 3 isoform X10

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    8. XM_017021800.2 → XP_016877289.1  neurexin 3 isoform X23

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    9. XM_011537366.2 → XP_011535668.1  neurexin 3 isoform X4

      See identical proteins and their annotated locations for XP_011535668.1

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 417
      LamG; Laminin G domain
      cd00054
      Location:651 → 684
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1605 → 1640
      Syndecan; Syndecan domain
      pfam02210
      Location:903 → 1031
      Laminin_G_2; Laminin G domain

    10. XM_047431946.1 → XP_047287902.1  neurexin 3 isoform X18

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    11. XM_047431953.1 → XP_047287909.1  neurexin 3 isoform X29

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    12. XM_047431939.1 → XP_047287895.1  neurexin 3 isoform X5

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    13. XM_011537370.2 → XP_011535672.1  neurexin 3 isoform X19

      See identical proteins and their annotated locations for XP_011535672.1

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:286 → 417
      LamG; Laminin G domain
      cd00054
      Location:651 → 684
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1501 → 1536
      Syndecan; Syndecan domain
      pfam02210
      Location:903 → 1031
      Laminin_G_2; Laminin G domain

    14. XM_006720322.3 → XP_006720385.1  neurexin 3 isoform X3

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:282 → 421
      LamG; Laminin G domain
      cd00054
      Location:655 → 688
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1609 → 1644
      Syndecan; Syndecan domain
      pfam02210
      Location:907 → 1035
      Laminin_G_2; Laminin G domain

    15. XM_047431945.1 → XP_047287901.1  neurexin 3 isoform X17

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    16. XM_024449752.2 → XP_024305520.1  neurexin 3 isoform X42

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:282 → 421
      LamG; Laminin G domain
      cd00054
      Location:655 → 688
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1398 → 1433
      Syndecan; Syndecan domain
      pfam02210
      Location:907 → 1035
      Laminin_G_2; Laminin G domain

    17. XM_047431950.1 → XP_047287906.1  neurexin 3 isoform X24

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    18. XM_047431957.1 → XP_047287913.1  neurexin 3 isoform X34

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    19. XM_047431951.1 → XP_047287907.1  neurexin 3 isoform X25

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    20. XM_017021794.2 → XP_016877283.1  neurexin 3 isoform X6

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    21. XM_047431947.1 → XP_047287903.1  neurexin 3 isoform X20

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    22. XM_047431954.1 → XP_047287910.1  neurexin 3 isoform X30

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    23. XM_047431940.1 → XP_047287896.1  neurexin 3 isoform X7

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    24. XM_017021805.2 → XP_016877294.1  neurexin 3 isoform X31

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    25. XM_047431942.1 → XP_047287898.1  neurexin 3 isoform X11

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    26. XM_047431952.1 → XP_047287908.1  neurexin 3 isoform X26

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    27. XM_047431958.1 → XP_047287914.1  neurexin 3 isoform X35

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    28. XM_047431943.1 → XP_047287899.1  neurexin 3 isoform X12

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    29. XM_047431959.1 → XP_047287915.1  neurexin 3 isoform X36

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    30. XM_017021798.2 → XP_016877287.1  neurexin 3 isoform X8

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    31. XM_047431948.1 → XP_047287904.1  neurexin 3 isoform X21

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    32. XM_047431955.1 → XP_047287911.1  neurexin 3 isoform X32

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    33. XM_047431941.1 → XP_047287897.1  neurexin 3 isoform X9

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    34. XM_047431949.1 → XP_047287905.1  neurexin 3 isoform X22

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    35. XM_047431956.1 → XP_047287912.1  neurexin 3 isoform X33

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    36. XM_024449751.2 → XP_024305519.1  neurexin 3 isoform X13

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1562 → 1597
      Syndecan; Syndecan domain
      pfam02210
      Location:890 → 1018
      Laminin_G_2; Laminin G domain

    37. XM_047431944.1 → XP_047287900.1  neurexin 3 isoform X14

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    38. XM_024449753.2 → XP_024305521.1  neurexin 3 isoform X37

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Conserved Domains (6) summary
      smart00282
      Location:282 → 413
      LamG; Laminin G domain
      cd00054
      Location:647 → 680
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:35 → 181
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:202 → 232
      EGF; EGF-like domain
      pfam01034
      Location:1351 → 1386
      Syndecan; Syndecan domain
      pfam02210
      Location:890 → 1018
      Laminin_G_2; Laminin G domain

    39. XM_047431960.1 → XP_047287916.1  neurexin 3 isoform X38

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    40. XM_047431961.1 → XP_047287917.1  neurexin 3 isoform X39

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    41. XM_047431964.1 → XP_047287920.1  neurexin 3 isoform X41

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    42. XM_047431963.1 → XP_047287919.1  neurexin 3 isoform X40

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0
      Related
      ENSP00000450683.1, ENST00000554738.5

    RNA

    1. XR_001750609.1 RNA Sequence

    2. XR_007064051.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      72379419..74078363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377024.1 → XP_054232999.1  neurexin 3 isoform X1

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    2. XM_054377038.1 → XP_054233013.1  neurexin 3 isoform X15

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    3. XM_054377050.1 → XP_054233025.1  neurexin 3 isoform X27

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    4. XM_054377025.1 → XP_054233000.1  neurexin 3 isoform X2

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    5. XM_054377039.1 → XP_054233014.1  neurexin 3 isoform X16

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    6. XM_054377051.1 → XP_054233026.1  neurexin 3 isoform X28

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    7. XM_054377033.1 → XP_054233008.1  neurexin 3 isoform X10

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    8. XM_054377046.1 → XP_054233021.1  neurexin 3 isoform X23

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    9. XM_054377027.1 → XP_054233002.1  neurexin 3 isoform X4

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    10. XM_054377041.1 → XP_054233016.1  neurexin 3 isoform X18

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    11. XM_054377052.1 → XP_054233027.1  neurexin 3 isoform X29

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    12. XM_054377028.1 → XP_054233003.1  neurexin 3 isoform X5

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    13. XM_054377042.1 → XP_054233017.1  neurexin 3 isoform X19

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    14. XM_054377026.1 → XP_054233001.1  neurexin 3 isoform X3

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    15. XM_054377040.1 → XP_054233015.1  neurexin 3 isoform X17

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    16. XM_054377065.1 → XP_054233040.1  neurexin 3 isoform X42

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    17. XM_054377047.1 → XP_054233022.1  neurexin 3 isoform X24

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    18. XM_054377057.1 → XP_054233032.1  neurexin 3 isoform X34

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    19. XM_054377048.1 → XP_054233023.1  neurexin 3 isoform X25

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    20. XM_054377029.1 → XP_054233004.1  neurexin 3 isoform X6

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    21. XM_054377043.1 → XP_054233018.1  neurexin 3 isoform X20

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    22. XM_054377053.1 → XP_054233028.1  neurexin 3 isoform X30

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    23. XM_054377030.1 → XP_054233005.1  neurexin 3 isoform X7

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    24. XM_054377054.1 → XP_054233029.1  neurexin 3 isoform X31

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    25. XM_054377034.1 → XP_054233009.1  neurexin 3 isoform X11

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    26. XM_054377049.1 → XP_054233024.1  neurexin 3 isoform X26

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    27. XM_054377058.1 → XP_054233033.1  neurexin 3 isoform X35

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    28. XM_054377035.1 → XP_054233010.1  neurexin 3 isoform X12

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    29. XM_054377059.1 → XP_054233034.1  neurexin 3 isoform X36

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    30. XM_054377031.1 → XP_054233006.1  neurexin 3 isoform X8

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    31. XM_054377044.1 → XP_054233019.1  neurexin 3 isoform X21

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    32. XM_054377055.1 → XP_054233030.1  neurexin 3 isoform X32

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    33. XM_054377032.1 → XP_054233007.1  neurexin 3 isoform X9

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    34. XM_054377045.1 → XP_054233020.1  neurexin 3 isoform X22

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    35. XM_054377056.1 → XP_054233031.1  neurexin 3 isoform X33

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    36. XM_054377036.1 → XP_054233011.1  neurexin 3 isoform X13

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    37. XM_054377037.1 → XP_054233012.1  neurexin 3 isoform X14

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    38. XM_054377060.1 → XP_054233035.1  neurexin 3 isoform X37

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    39. XM_054377061.1 → XP_054233036.1  neurexin 3 isoform X38

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    40. XM_054377062.1 → XP_054233037.1  neurexin 3 isoform X39

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    41. XM_054377064.1 → XP_054233039.1  neurexin 3 isoform X41

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    42. XM_054377063.1 → XP_054233038.1  neurexin 3 isoform X40

      UniProtKB/Swiss-Prot
      A6NGR4, A7MD34, O95378, Q8IUE3, Q9NS47, Q9P1V3, Q9P1V6, Q9UIE2, Q9UIE3, Q9ULA5, Q9Y486, Q9Y4C0

    RNA

    1. XR_008488900.1 RNA Sequence

    2. XR_008488901.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HDB5.4 GenPept UniProtKB/Swiss-Prot:Q9HDB5
    Q9Y4C0.4 GenPept UniProtKB/Swiss-Prot:Q9Y4C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous