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    NAA16 N-alpha-acetyltransferase 16, NatA auxiliary subunit [ Homo sapiens (human) ]

    Gene ID: 79612, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NAA16provided by HGNC
    Official Full Name
    N-alpha-acetyltransferase 16, NatA auxiliary subunitprovided by HGNC
    Primary source
    HGNC:HGNC:26164
    See related
    Ensembl:ENSG00000172766 MIM:619497; AllianceGenome:HGNC:26164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NARG1L
    Summary
    Enables ribosome binding activity. Involved in N-terminal protein amino acid acetylation; negative regulation of apoptotic process; and protein stabilization. Located in cytosol. Part of NatA complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 2.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NAA16 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (41311267..41377030)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (40530410..40596042)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41885403..41951166)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene mitochondrial translation release factor 1 Neighboring gene uncharacterized LOC105370173 Neighboring gene Rac family small GTPase 1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:41916345-41916845 Neighboring gene RNA, U6 small nuclear 57, pseudogene Neighboring gene tubulin beta pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 5068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:41995454-41995988 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:41995989-41996521 Neighboring gene olfactory receptor family 7 subfamily E member 36 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. Arnesen T, et al. BMC Biochem, 2006 Apr 25. PMID 16638120, Free PMC Article
    2. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). Arnesen T, et al. BMC Biochem, 2009 May 29. PMID 19480662, Free PMC Article
    3. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. Polevoda B, et al. BMC Proc, 2009 Aug 4. PMID 19660095, Free PMC Article
    4. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. Yu Y, et al. Genome Res, 2001 Aug. PMID 11483580, Free PMC Article
    5. Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. Bararia D, et al. Leukemia, 2008 Apr. PMID 18239623

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40612, DKFZp686O08147

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-terminal protein amino acid acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Names
    NARG1-like protein
    NMDA receptor-regulated 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110798.2 → NP_001104268.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 3

      See identical proteins and their annotated locations for NP_001104268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several coding exons and differs in the 3' UTR, compared to variant 1, resulting in a shorter protein (isoform 3) with a unique C-terminus, compared to isoform 1.
      Source sequence(s)
      AL590665, BC064592, BE501152, DB078940
      Consensus CDS
      CCDS45044.1
      UniProtKB/Swiss-Prot
      Q6N069
      Related
      ENSP00000386103.3, ENST00000403412.7
      Conserved Domains (3) summary
      sd00006
      Location:82 → 108
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:87 → 113
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:82 → 145
      TPR_11; TPR repeat

    2. NM_018527.4 → NP_060997.2  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 2

      See identical proteins and their annotated locations for NP_060997.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon and several 3' exons but has an alternate 3' segment, compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL590665, BC032318, DB078940
      UniProtKB/Swiss-Prot
      Q6N069
      Related
      ENST00000476980.5
      Conserved Domains (3) summary
      sd00006
      Location:82 → 108
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:87 → 113
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:82 → 145
      TPR_11; TPR repeat

    3. NM_024561.5 → NP_078837.3  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform 1

      See identical proteins and their annotated locations for NP_078837.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK097224, AL590665, AL731858, AL833341, DB078940
      Consensus CDS
      CCDS9379.1
      UniProtKB/Swiss-Prot
      B0QZ59, Q5VSP9, Q6N069, Q6P2D5, Q8N5J3, Q8N870
      UniProtKB/TrEMBL
      A4FU51
      Related
      ENSP00000368716.3, ENST00000379406.8
      Conserved Domains (4) summary
      sd00006
      Location:82 → 108
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:87 → 113
      TPR_1; Tetratricopeptide repeat
      pfam12569
      Location:187 → 698
      NARP1; NMDA receptor-regulated protein 1
      pfam13414
      Location:82 → 145
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      41311267..41377030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719866.4 → XP_006719929.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1

      Conserved Domains (4) summary
      sd00006
      Location:82 → 108
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:87 → 113
      TPR_1; Tetratricopeptide repeat
      pfam12569
      Location:187 → 638
      NARP1; NMDA receptor-regulated protein 1
      pfam13414
      Location:82 → 145
      TPR_11; TPR repeat

    2. XM_011535228.3 → XP_011533530.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X3

      See identical proteins and their annotated locations for XP_011533530.1

      UniProtKB/Swiss-Prot
      Q6N069
      Related
      ENSP00000432364.1, ENST00000464857.5
      Conserved Domains (3) summary
      sd00006
      Location:82 → 108
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:87 → 113
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:82 → 145
      TPR_11; TPR repeat

    3. XM_047430611.1 → XP_047286567.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X4

    4. XM_017020746.3 → XP_016876235.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X7

    5. XM_017020745.3 → XP_016876234.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X5

    6. XM_047430612.1 → XP_047286568.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X6

    7. XM_047430610.1 → XP_047286566.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      40530410..40596042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374961.1 → XP_054230936.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1

    2. XM_054374963.1 → XP_054230938.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X3

    3. XM_054374964.1 → XP_054230939.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X4

    4. XM_054374967.1 → XP_054230942.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X7

    5. XM_054374966.1 → XP_054230941.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X5

    6. XM_054374965.1 → XP_054230940.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X8

    7. XM_054374962.1 → XP_054230937.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6N069.2 GenPept UniProtKB/Swiss-Prot:Q6N069

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