ZNF502 zinc finger protein 502 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF502provided by HGNC
Official Full Name: zinc finger protein 502provided by HGNC
Primary source: HGNC:HGNC:23718
See related: Ensembl:ENSG00000196653 AllianceGenome:HGNC:23718
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation by host of viral process and viral release from host cell. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis (RPKM 2.5), prostate (RPKM 2.1) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 3p21.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (44712660..44723831)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (44728342..44739513)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (44754152..44765323)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ENAH-202 promotes cancer progression in oral squamous cell carcinoma by regulating ZNF502/VIM axis.
Title: ENAH-202 promotes cancer progression in oral squamous cell carcinoma by regulating ZNF502/VIM axis.
Results present initial characterization of key proteins Cav2 and CFL1 as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 protein which appears to interact with RSV M in the nucleus.
Title: New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:252106 (e-PCR)
- UniSTS:156330

RH102398 (e-PCR)
- UniSTS:96732

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation by host of viral process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in viral release from host cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 502

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134440.2 → NP_001127912.1 zinc finger protein 502

See identical proteins and their annotated locations for NP_001127912.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.

Source sequence(s)

AC098649, AC124045

Consensus CDS

CCDS2719.1

UniProtKB/Swiss-Prot

Q8TBZ5

Conserved Domains (2) summary

COG5048
Location:151 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001134441.2 → NP_001127913.1 zinc finger protein 502

See identical proteins and their annotated locations for NP_001127913.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.

Source sequence(s)

AC098649, AC124045

Consensus CDS

CCDS2719.1

UniProtKB/Swiss-Prot

Q8TBZ5

Related

ENSP00000397390.1, ENST00000449836.5

Conserved Domains (2) summary

COG5048
Location:151 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001134442.3 → NP_001127914.1 zinc finger protein 502

See identical proteins and their annotated locations for NP_001127914.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.

Source sequence(s)

AC098649, AC124045

Consensus CDS

CCDS2719.1

UniProtKB/Swiss-Prot

Q8TBZ5

Related

ENSP00000406469.2, ENST00000436624.7

Conserved Domains (2) summary

COG5048
Location:151 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001282880.2 → NP_001269809.1 zinc finger protein 502

See identical proteins and their annotated locations for NP_001269809.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents the longest transcript. Variants 1-5 encode the same protein.

Source sequence(s)

AC098649, AC124045

Consensus CDS

CCDS2719.1

UniProtKB/Swiss-Prot

Q8TBZ5

Conserved Domains (2) summary

COG5048
Location:151 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_033210.5 → NP_149987.2 zinc finger protein 502

See identical proteins and their annotated locations for NP_149987.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-5 encode the same protein.

Source sequence(s)

AC098649, AC124045

Consensus CDS

CCDS2719.1

UniProtKB/Swiss-Prot

Q8TBZ5

Related

ENSP00000296091.4, ENST00000296091.8

Conserved Domains (2) summary

COG5048
Location:151 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]