Sftpa1 surfactant associated protein A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sftpa1provided by MGI
Official Full Name: surfactant associated protein A1provided by MGI
Primary source: MGI:MGI:109518
See related: Ensembl:ENSMUSG00000021789 AllianceGenome:MGI:109518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SP-A; Sftp1; Sftp-1
Summary: Predicted to enable carbohydrate binding activity and metal ion binding activity. Predicted to be involved in positive regulation of phagocytosis. Located in collagen-containing extracellular matrix. Is expressed in extraembryonic component; lung; lung surfactant; and placenta. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to human SFTPA1 (surfactant protein A1) and SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward lung adult (RPKM 365.5) See more
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Genomic context

Location:: 14 B; 14 22.36 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (40853745..40858330)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (41131788..41136373)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection.
Title: Surfactant protein A modulates neuroinflammation in adult mice upon pulmonary infection.
Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx.
Title: Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx.
Disruption of the SP-A/SP-R210L (MYO18Aalpha) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation.
Title: Disruption of the SP-A/SP-R210(L) (MYO18Aα) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation.
Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.
Title: Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.
Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain.
Title: Negligible role for pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC) in the nasopharyngeal colonization of mice with a serotype 6B pneumococcal strain.
Surfactant Protein A can Affect the Surface Tension of the Eustachian Tube and Macrophage Migration.
Title: Surfactant Protein A can Affect the Surface Tension of the Eustachian Tube and Macrophage Migration.
Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries.
Title: Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries.
Surfactant protein a attenuates generalized and localized neuroinflammation in neonatal mice.
Title: Surfactant protein a attenuates generalized and localized neuroinflammation in neonatal mice.
Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.
Title: Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.
Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.
Title: Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548178

Sftpa1 (e-PCR), detects polymorphism
- UniSTS:516721

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pulmonary surfactant-associated protein A

Names: PSAP; PSP-A; surfactant pulmonary associated protein A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023134.5 → NP_075623.2 pulmonary surfactant-associated protein A precursor

See identical proteins and their annotated locations for NP_075623.2

Status: VALIDATED

Source sequence(s)

AC124400

Consensus CDS

CCDS26960.1

UniProtKB/Swiss-Prot

P35242

UniProtKB/TrEMBL

Q9CQI1

Related

ENSMUSP00000129696.2, ENSMUST00000170719.2

Conserved Domains (2) summary

cd03591
Location:136 → 248

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:27 → 98

Collagen; Collagen triple helix repeat (20 copies)