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    Tmem106a transmembrane protein 106A [ Mus musculus (house mouse) ]

    Gene ID: 217203, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem106aprovided by MGI
    Official Full Name
    transmembrane protein 106Aprovided by MGI
    Primary source
    MGI:MGI:1922056
    See related
    Ensembl:ENSMUSG00000034947 AllianceGenome:MGI:1922056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610008L10Rik
    Summary
    Involved in several processes, including glycoprotein biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Located in plasma membrane. Orthologous to human TMEM106A (transmembrane protein 106A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 64.7), placenta adult (RPKM 25.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem106a in Genome Data Viewer
    Location:
    11 D; 11 65.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101473068..101482612)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101582242..101591788)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene breast cancer 1, early onset Neighboring gene STARR-positive B cell enhancer mm9_chr11:101413133-101413434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101413898-101414007 Neighboring gene NBR1, autophagy cargo receptor Neighboring gene coiled coil domain containing 200 Neighboring gene STARR-seq mESC enhancer starr_30771 Neighboring gene predicted gene, 26316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-κB signaling pathways in macrophages. Zhang X, et al. Clin Exp Immunol, 2021 Jan. PMID 33006758, Free PMC Article
    2. Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways. Dai H, et al. Sci Rep, 2015 Jul 28. PMID 26215746, Free PMC Article
    3. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-kappaB signaling pathways in macrophages.
      Title: Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-κB signaling pathways in macrophages.
    2. data suggest that mouse Tmem106a might be a new trigger of macrophage activation and have some influence toward the M1 state through the activation of the MAPKs and NF-kappaB pathway
      Title: Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30290, MGC37887

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in CD80 biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CD86 biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nitric oxide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 106A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359325.1 → NP_001346254.1  transmembrane protein 106A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK149650, AK150285
      Consensus CDS
      CCDS25476.1
      UniProtKB/Swiss-Prot
      Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
      Conserved Domains (1) summary
      pfam07092
      Location:24 → 251
      DUF1356; Protein of unknown function (DUF1356)

    2. NM_001359326.1 → NP_001346255.1  transmembrane protein 106A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK149650, AK150285, AL590994, BY199928
      Consensus CDS
      CCDS25476.1
      UniProtKB/Swiss-Prot
      Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
      Related
      ENSMUSP00000097971.3, ENSMUST00000100403.9
      Conserved Domains (1) summary
      pfam07092
      Location:24 → 251
      DUF1356; Protein of unknown function (DUF1356)

    3. NM_001359327.1 → NP_001346256.1  transmembrane protein 106A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK149650, AK150285, BY199928
      Consensus CDS
      CCDS25476.1
      UniProtKB/Swiss-Prot
      Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
      Conserved Domains (1) summary
      pfam07092
      Location:24 → 251
      DUF1356; Protein of unknown function (DUF1356)

    4. NM_144830.3 → NP_659079.1  transmembrane protein 106A

      See identical proteins and their annotated locations for NP_659079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK146019
      Consensus CDS
      CCDS25476.1
      UniProtKB/Swiss-Prot
      Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
      Related
      ENSMUSP00000045832.8, ENSMUST00000039581.14
      Conserved Domains (1) summary
      pfam07092
      Location:24 → 251
      DUF1356; Protein of unknown function (DUF1356)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101473068..101482612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC04.1 GenPept UniProtKB/Swiss-Prot:Q8VC04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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