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    Piezo2 piezo-type mechanosensitive ion channel component 2 [ Mus musculus (house mouse) ]

    Gene ID: 667742, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Piezo2provided by MGI
    Official Full Name
    piezo-type mechanosensitive ion channel component 2provided by MGI
    Primary source
    MGI:MGI:1918781
    See related
    Ensembl:ENSMUSG00000041482 AllianceGenome:MGI:1918781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam38b; Fam38b2; 5930434P17; 9030411M15Rik; 9430028L06Rik
    Summary
    Enables mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Involved in detection of mechanical stimulus involved in sensory perception and monoatomic cation transport. Acts upstream of or within regulation of membrane potential. Located in cuticular plate; neuronal cell body membrane; and stereocilium. Is expressed in dorsal root ganglion and lung. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 12.4), lung adult (RPKM 5.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Piezo2 in Genome Data Viewer
    Location:
    18 E1; 18 35.95 cM
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63143284..63520787, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (63010213..63387716, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene adenomatosis polyposis coli down-regulated 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein gamma Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene predicted gene, 36651 Neighboring gene STARR-seq mESC enhancer starr_44785 Neighboring gene STARR-seq mESC enhancer starr_44786 Neighboring gene STARR-seq mESC enhancer starr_44787 Neighboring gene STARR-seq mESC enhancer starr_44788 Neighboring gene predicted gene, 26972 Neighboring gene STARR-seq mESC enhancer starr_44790 Neighboring gene predicted gene, 23581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity. Gabrielle M, et al. Nat Commun, 2024 Aug 15. PMID 39147733, Free PMC Article
    2. Piezo2 protein: A novel regulator of tumor angiogenesis and hyperpermeability. Yang H, et al. Oncotarget, 2016 Jul 12. PMID 27329839, Free PMC Article
    3. Midpalatal Suture: Single-Cell RNA-Seq Reveals Intramembrane Ossification and Piezo2 Chondrogenic Mesenchymal Cell Involvement. Gao L, et al. Cells, 2022 Nov 12. PMID 36429014, Free PMC Article
    4. Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2. Hoffman BU, et al. Proc Natl Acad Sci U S A, 2022 May 24. PMID 35580186, Free PMC Article
    5. Excessive mechanotransduction in sensory neurons causes joint contractures. Ma S, et al. Science, 2023 Jan 13. PMID 36634173, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Piezo2 voltage-block regulates mechanical pain sensitivity.
      Title: Piezo2 voltage-block regulates mechanical pain sensitivity.
    2. Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways.
      Title: Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways.
    3. Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity.
      Title: Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity.
    4. Plp1-expresssing perineuronal DRG cells facilitate colonic and somatic chronic mechanical pain involving Piezo2 upregulation in DRG neurons.
      Title: Plp1-expresssing perineuronal DRG cells facilitate colonic and somatic chronic mechanical pain involving Piezo2 upregulation in DRG neurons.
    5. Piezo1 and Piezo2 collectively regulate jawbone development.
      Title: Piezo1 and Piezo2 collectively regulate jawbone development.
    6. Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.
      Title: Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.
    7. Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice.
      Title: Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice.
    8. Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.
      Title: Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.
    9. PIEZO2 and perineal mechanosensation are essential for sexual function.
      Title: PIEZO2 and perineal mechanosensation are essential for sexual function.
    10. Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.
      Title: Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23403, MGC182702

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of mechanical stimulus involved in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cuticular plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    piezo-type mechanosensitive ion channel component 2
    Names
    family with sequence similarity 38, member B
    family with sequence similarity 38, member B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039485.5 → NP_001034574.4  piezo-type mechanosensitive ion channel component 2

      Status: VALIDATED

      Source sequence(s)
      AC124391, AC132378, AC140554, AC162804
      Consensus CDS
      CCDS29296.2
      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      UniProtKB/TrEMBL
      E9QNW4
      Related
      ENSMUSP00000040019.6, ENSMUST00000047480.13
      Conserved Domains (2) summary
      pfam12166
      Location:2412 → 2821
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1383 → 1614
      PIEZO; Piezo

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      63143284..63520787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526169.4 → XP_006526232.1  piezo-type mechanosensitive ion channel component 2 isoform X4

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:2417 → 2826
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1355 → 1622
      PIEZO; Piezo

    2. XM_006526168.4 → XP_006526231.1  piezo-type mechanosensitive ion channel component 2 isoform X3

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:2418 → 2827
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1356 → 1623
      PIEZO; Piezo

    3. XM_006526173.4 → XP_006526236.1  piezo-type mechanosensitive ion channel component 2 isoform X7

      UniProtKB/TrEMBL
      A0A494B9V6, S4R2S0
      Related
      ENSMUSP00000138758.3, ENSMUST00000183217.9
      Conserved Domains (2) summary
      pfam12166
      Location:2341 → 2750
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1368 → 1602
      PIEZO; Piezo

    4. XM_006526167.4 → XP_006526230.1  piezo-type mechanosensitive ion channel component 2 isoform X2

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:2430 → 2839
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1368 → 1635
      PIEZO; Piezo

    5. XM_036161249.1 → XP_036017142.1  piezo-type mechanosensitive ion channel component 2 isoform X8

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      UniProtKB/TrEMBL
      A0A2H4UKA3
      Conserved Domains (2) summary
      pfam12166
      Location:2455 → 2864
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1393 → 1660
      PIEZO; Piezo

    6. XM_006526170.4 → XP_006526233.1  piezo-type mechanosensitive ion channel component 2 isoform X5

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:2398 → 2807
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1369 → 1603
      PIEZO; Piezo

    7. XM_006526172.4 → XP_006526235.1  piezo-type mechanosensitive ion channel component 2 isoform X6

      UniProtKB/TrEMBL
      A0A494B9V6
      Conserved Domains (2) summary
      pfam12166
      Location:2375 → 2784
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1369 → 1636
      PIEZO; Piezo

    8. XM_006526166.4 → XP_006526229.1  piezo-type mechanosensitive ion channel component 2 isoform X1

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:2431 → 2840
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1369 → 1636
      PIEZO; Piezo

    RNA

    1. XR_386006.4 RNA Sequence

    2. XR_001782388.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172629.1: Suppressed sequence

      Description
      NM_172629.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CD54.2 GenPept UniProtKB/Swiss-Prot:Q8CD54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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