DON1 Don1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: DON1
Official Full Name: Don1p
Primary source: SGD:S000002681
Locus tag: YDR273W
See related: AllianceGenome:SGD:S000002681; FungiDB:YDR273W; VEuPathDB:YDR273W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ubiquitin binding activity and ubiquitin conjugating enzyme binding activity. Involved in ascospore wall assembly. Located in prospore membrane leading edge. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ascospore wall assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in prospore membrane	IDA Inferred from Direct Assay more info	PubMed
located_in prospore membrane	IEA Inferred from Electronic Annotation more info
located_in prospore membrane leading edge	IDA Inferred from Direct Assay more info	PubMed

NP_010559.3

Meiosis-specific component of the spindle pole body; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane (PSM) during meiosis II; required for PSM growth and closure; DON1 has a paralog, CUE5, that arose from the whole genome

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The following sections contain reference sequences that belong to a specific genome build. Explain