Rubcnl RUN and cysteine rich domain containing beclin 1 interacting protein like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rubcnlprovided by MGI
Official Full Name: RUN and cysteine rich domain containing beclin 1 interacting protein likeprovided by MGI
Primary source: MGI:MGI:2685590
See related: Ensembl:ENSMUSG00000034959 AllianceGenome:MGI:2685590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm744; Gm911; Kiaa0226l; 5031414D18Rik
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in autophagosome maturation; regulation of glycogen metabolic process; and regulation of lipid metabolic process. Predicted to be located in cytoplasmic vesicle. Predicted to be active in autophagosome membrane. Orthologous to human RUBCNL (rubicon like autophagy enhancer). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 8.9), mammary gland adult (RPKM 2.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 39.53 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (75253467..75289977)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (75015987..75052537)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mTORC1 and GSK3-TIP60 signaling converge to modulate autophagosome maturation and lipid metabolism through Pacer.
Title: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagosome-endosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome-endosome fusion	ISO Inferred from Sequence Orthology more info
involved_in autophagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in autophagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein associated with UVRAG as autophagy enhancer

Names: pacer; protein RUBCNL-like; protein Rubicon-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374214.1 → NP_001361143.1 protein associated with UVRAG as autophagy enhancer isoform 2

Status: VALIDATED

Source sequence(s)

AC146617

Conserved Domains (1) summary

pfam13901
Location:252 → 447

zf-RING_9; Putative zinc-RING and/or ribbon
NM_198642.2 → NP_941044.3 protein associated with UVRAG as autophagy enhancer isoform 1

See identical proteins and their annotated locations for NP_941044.3

Status: VALIDATED

Source sequence(s)

AC146617

Consensus CDS

CCDS36977.1

UniProtKB/TrEMBL

F8WGX2, Q7TPZ3

Related

ENSMUSP00000045566.8, ENSMUST00000036072.8

Conserved Domains (1) summary

pfam13901
Location:464 → 659

zf-RING_9; Putative zinc-RING and/or ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

75253467..75289977

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158642.1 → XP_036014535.1 protein associated with UVRAG as autophagy enhancer isoform X2

UniProtKB/TrEMBL

Q7TPZ3

Conserved Domains (1) summary

pfam13901
Location:435 → 537

zf-RING_9; Putative zinc-RING and/or ribbon
XM_030247841.2 → XP_030103701.1 protein associated with UVRAG as autophagy enhancer isoform X4
XM_036158643.1 → XP_036014536.1 protein associated with UVRAG as autophagy enhancer isoform X3
XM_036158644.1 → XP_036014537.1 protein associated with UVRAG as autophagy enhancer isoform X5
XM_011245078.4 → XP_011243380.1 protein associated with UVRAG as autophagy enhancer isoform X1

See identical proteins and their annotated locations for XP_011243380.1

UniProtKB/TrEMBL

F8WGX2, Q7TPZ3

Conserved Domains (1) summary

pfam13901
Location:464 → 659

zf-RING_9; Putative zinc-RING and/or ribbon