TUB2 beta-tubulin [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TUB2
Official Full Name: beta-tubulin
Primary source: SGD:S000001857
Locus tag: YFL037W
See related: AllianceGenome:SGD:S000001857; FungiDB:YFL037W; VEuPathDB:YFL037W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ARM10; SHE8
Summary: Enables GTPase activity. A structural constituent of cytoskeleton. Involved in cytoplasmic microtubule organization; mitotic spindle assembly; and mitotic spindle elongation. Part of tubulin complex. Used to study several diseases, including Pick's disease; autosomal dominant macrothrombocytopenia TUBB1-related; complex cortical dysplasia with other brain malformations (multiple); cranial nerve disease (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Leber congenital amaurosis with early-onset deafness; autosomal dominant macrothrombocytopenia TUBB1-related; complex cortical dysplasia with other brain malformations (multiple); congenital fibrosis of the extraocular muscles (multiple); and congenital symmetric circumferential skin creases 1. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TUB2 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (56336..57709)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Of the six different point mutations generated in TUB2, four (A296T, R306H, V333W, and N337L) located in the peloruside binding site on beta-tubulin gave resistance to yeast as expected
Title: Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.
The polymerization blocked forms of alphabeta-tubulin give a lethal phenotype when expressed in cells.
Title: Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of tubulin complex	IDA Inferred from Direct Assay more info	PubMed
part_of tubulin complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: beta-tubulin

NP_116616.1

Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria