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    Adamts10 ADAM metallopeptidase with thrombospondin type 1 motif 10 [ Mus musculus (house mouse) ]

    Gene ID: 224697, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adamts10provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 10provided by MGI
    Primary source
    MGI:MGI:2449112
    See related
    Ensembl:ENSMUSG00000024299 AllianceGenome:MGI:2449112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znmp; Adam-ts10; Adamts-10; 9430006O18
    Summary
    This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate a functional, zinc-dependent metallopeptidase enzyme. [provided by RefSeq, Jul 2016]
    Expression
    Broad expression in ovary adult (RPKM 71.3), lung adult (RPKM 70.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adamts10 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33742620..33772756)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33523646..33553782)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene actin-like 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33621106-33621293 Neighboring gene NFIL3 like basic leucine zipper Neighboring gene STARR-seq mESC enhancer starr_42406 Neighboring gene myosin IF Neighboring gene STARR-seq mESC enhancer starr_42407 Neighboring gene STARR-seq mESC enhancer starr_42408 Neighboring gene zinc finger protein 414

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC118623

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microfibril ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 10
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
    zinc metalloendopeptidase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329143.1NP_001316072.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Conserved Domains (6) summary
      smart00209
      Location:151203
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:307419
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:671703
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:70138
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:549603
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:155
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    2. NM_001329147.1NP_001316076.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Conserved Domains (6) summary
      smart00209
      Location:151203
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:307419
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:671703
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:70138
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:549603
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:155
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    3. NM_001329151.1NP_001316080.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Conserved Domains (5) summary
      PHA02682
      Location:394529
      PHA02682; ORF080 virion core protein; Provisional
      smart00209
      Location:74126
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:230342
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:594626
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:861
      ADAM_CR_2; ADAM cysteine-rich domain
    4. NM_001329152.1NP_001316081.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Conserved Domains (5) summary
      PHA02682
      Location:394529
      PHA02682; ORF080 virion core protein; Provisional
      smart00209
      Location:74126
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:230342
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:594626
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:861
      ADAM_CR_2; ADAM cysteine-rich domain
    5. NM_001329153.1NP_001316082.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Conserved Domains (4) summary
      smart00209
      Location:72124
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:228340
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592624
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:470524
      TSP1_ADAMTS; Thrombospondin type 1 domain
    6. NM_001329154.1NP_001316083.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Conserved Domains (4) summary
      smart00209
      Location:72124
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:228340
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592624
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:470524
      TSP1_ADAMTS; Thrombospondin type 1 domain
    7. NM_001329202.1NP_001316131.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AK169468, BC056427, CT030734
      Conserved Domains (4) summary
      smart00209
      Location:72124
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:228340
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592624
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:470524
      TSP1_ADAMTS; Thrombospondin type 1 domain
    8. NM_001329203.1NP_001316132.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AK169468, CT030734
    9. NM_001425316.1NP_001412245.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 3

      Status: REVIEWED

      Source sequence(s)
      CT030734
    10. NM_001425317.1NP_001412246.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      CT030734
    11. NM_001425318.1NP_001412247.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      CT030734
    12. NM_172619.4NP_766207.2  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_766207.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK076334, AK169468, BQ571453, CT030734
      Consensus CDS
      CCDS37566.1
      UniProtKB/Swiss-Prot
      P58459, Q497H1, Q78TI1, Q8CG28
      Related
      ENSMUSP00000084905.7, ENSMUST00000087623.13
      Conserved Domains (6) summary
      smart00209
      Location:550602
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:239454
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:239457
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:64179
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:706818
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10701102
      PLAC; PLAC (protease and lacunin) domain

    RNA

    1. NR_137626.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Related
      ENSMUST00000173013.8
    2. NR_137627.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Related
      ENSMUST00000173241.8
    3. NR_137628.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734
      Related
      ENSMUST00000173931.8
    4. NR_137629.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK042525, CT030734

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33742620..33772756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317411.3XP_017172900.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

      Conserved Domains (7) summary
      PHA02682
      Location:804939
      PHA02682; ORF080 virion core protein; Provisional
      smart00209
      Location:484536
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:173388
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:40114
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:640752
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10041036
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:403471
      ADAM_CR_2; ADAM cysteine-rich domain
    2. XM_017317418.2XP_017172907.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X4

      Conserved Domains (5) summary
      PHA02682
      Location:394529
      PHA02682; ORF080 virion core protein; Provisional
      smart00209
      Location:74126
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:230342
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:594626
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:861
      ADAM_CR_2; ADAM cysteine-rich domain
    3. XM_017317412.3XP_017172901.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X2

      Conserved Domains (6) summary
      smart00209
      Location:301353
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:1205
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:457569
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:821853
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:220288
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:699753
      TSP1_ADAMTS; Thrombospondin type 1 domain
    4. XM_036160532.1XP_036016425.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X5

      Conserved Domains (4) summary
      smart00209
      Location:72124
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:228340
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592624
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:470524
      TSP1_ADAMTS; Thrombospondin type 1 domain
    5. XM_036160531.1XP_036016424.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X3

      Conserved Domains (6) summary
      smart00209
      Location:151203
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:307419
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:671703
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:70138
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:549603
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:155
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    6. XM_017317428.2XP_017172917.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X5

      Conserved Domains (4) summary
      smart00209
      Location:72124
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:228340
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592624
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:470524
      TSP1_ADAMTS; Thrombospondin type 1 domain
    7. XM_030249704.2XP_030105564.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X4

      Conserved Domains (5) summary
      PHA02682
      Location:394529
      PHA02682; ORF080 virion core protein; Provisional
      smart00209
      Location:74126
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:230342
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:594626
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:861
      ADAM_CR_2; ADAM cysteine-rich domain
    8. XM_036160530.1XP_036016423.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X2

      Conserved Domains (6) summary
      smart00209
      Location:301353
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:1205
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:457569
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:821853
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:220288
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:699753
      TSP1_ADAMTS; Thrombospondin type 1 domain
    9. XM_017317424.2XP_017172913.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X5

      Related
      ENSMUST00000174104.8
      Conserved Domains (4) summary
      smart00209
      Location:72124
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:228340
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592624
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:470524
      TSP1_ADAMTS; Thrombospondin type 1 domain
    10. XM_030249703.2XP_030105563.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X4

      Conserved Domains (5) summary
      PHA02682
      Location:394529
      PHA02682; ORF080 virion core protein; Provisional
      smart00209
      Location:74126
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:230342
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:594626
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:861
      ADAM_CR_2; ADAM cysteine-rich domain

    RNA

    1. XR_004939515.1 RNA Sequence

    2. XR_001782065.3 RNA Sequence

      Related
      ENSMUST00000173030.8
    3. XR_003952109.1 RNA Sequence