U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LSG1 putative GTPase LSG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852779, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LSG1
    Official Full Name
    putative GTPase LSG1
    Primary source
    SGD:S000003067
    Locus tag
    YGL099W
    See related
    AllianceGenome:SGD:S000003067; FungiDB:YGL099W; VEuPathDB:YGL099W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KRE35
    Summary
    Enables mRNA binding activity. Involved in ribosomal large subunit assembly and ribosomal subunit export from nucleus. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LSG1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (314631..316553)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 5'-deoxynucleotidase Neighboring gene Seh1p Neighboring gene ncRNA Neighboring gene SNAP receptor USE1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1. Jaramillo-Ramírez J, et al. Biochim Biophys Acta Proteins Proteom, 2021 Jan. PMID 32916301
    2. Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization. Reynaud EG, et al. BMC Biol, 2005 Oct 7. PMID 16209721, Free PMC Article
    3. Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. Hedges J, et al. EMBO J, 2005 Feb 9. PMID 15660131, Free PMC Article
    4. Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit. Hedges J, et al. J Biol Chem, 2006 Dec 1. PMID 17015443
    5. Immature large ribosomal subunits containing the 7S pre-rRNA can engage in translation in Saccharomyces cerevisiae. Rodríguez-Galán O, et al. RNA Biol, 2015. PMID 26151772, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1.
      Title: Characterisation of the interaction of guanine nucleotides with ribosomal GTPase Lsg1.
    2. Nmd3 and Lsg1 together embrace helix 69 of the B2a intersubunit bridge, inducing base flipping that we suggest may activate the GTPase activity of Lsg1.
      Title: Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.
    3. correct loading of Rpl10p into 60S subunits is required for the release of Nmd3p from subunits by Lsg1p
      Title: Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative GTPase LSG1
    NP_011416.3
    • Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      314631..316553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180964.3 → NP_011416.3  TPA: putative GTPase LSG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011416.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU46, P53145
      UniProtKB/TrEMBL
      G2WE00, N1P5E5
      Conserved Domains (2) summary
      cd01857
      Location:187 → 394
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:167 → 528
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53145.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools