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    POP6 ribonuclease P/MRP protein subunit POP6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    POP6
    Official Full Name
    ribonuclease P/MRP protein subunit POP6
    Primary source
    SGD:S000003262
    Locus tag
    YGR030C
    See related
    AllianceGenome:SGD:S000003262; FungiDB:YGR030C; VEuPathDB:YGR030C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA primary transcript binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Located in cytosol and nucleus. Part of nucleolar ribonuclease P complex; ribonuclease MRP complex; and telomerase holoenzyme complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See POP6 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (545681..546157, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene Imo32p Neighboring gene Nag1p Neighboring gene 1,3-beta-glucan synthase GSC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain. Perederina A, et al. EMBO J, 2010 Feb 17. PMID 20075859, Free PMC Article
    2. Footprinting analysis of interactions between the largest eukaryotic RNase P/MRP protein Pop1 and RNase P/MRP RNA components. Fagerlund RD, et al. RNA, 2015 Sep. PMID 26135751, Free PMC Article
    3. Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7. Perederina A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jan 1. PMID 20057077, Free PMC Article
    4. Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P. Perederina A, et al. RNA Biol, 2023 Jan. PMID 37074161, Free PMC Article
    5. Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs. Perederina A, et al. RNA, 2007 Oct. PMID 17717080, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In pop mutants, TLC1 is more abundant, telomeres are short, and TLC1 accumulates in the cytoplasm. Although Est1/2 binding to TLC1 occurs at normal levels, Est1 (and hence Est3) binding is highly unstable.
      Title: Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP.
    2. Study reports that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme.
      Title: Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.
    3. Crystal of Pop6 (18.2 kDa) and Pop7 (15.8 kDa) were obtained. They belonged to space group P4(2)22 (unit-cell parameters a = b = 127.2, c = 76.8 A, alpha = beta = gamma = 90 degrees ) and diffracted to 3.25 A resolution
      Title: Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7.
    4. Footprint analysis of the interaction between the Pop6/7 heterodimer and the RNase mitochondrial RNA-processing RNA, combined with gel mobility assays, demonstrates that the Pop6/7 complex binds to a conserved region of the P3 domain.
      Title: Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ribonuclease MRP activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intronic box C/D snoRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease P/MRP protein subunit POP6
    NP_011544.1
    • Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      545681..546157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181159.1 → NP_011544.1  TPA: ribonuclease P/MRP protein subunit POP6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUG5, P53218
      UniProtKB/TrEMBL
      E9P995, G2WEC0, N1P9U6
      Conserved Domains (1) summary
      pfam01918
      Location:49 → 118
      Alba
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53218.1

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