TMA108 Tma108p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TMA108
Official Full Name: Tma108p
Primary source: SGD:S000001399
Locus tag: YIL137C
See related: AllianceGenome:SGD:S000001399; FungiDB:YIL137C; VEuPathDB:YIL137C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TAE3
Summary: Enables nascent polypeptide-associated complex binding activity. Involved in regulation of cytoplasmic translation and ribosome biogenesis. Located in cytoplasm. Part of nascent polypeptide-associated complex. Human ortholog(s) of this gene implicated in cervix carcinoma and type 2 diabetes mellitus. Orthologous to several human genes including ANPEP (alanyl aminopeptidase, membrane); ERAP1 (endoplasmic reticulum aminopeptidase 1); and ERAP2 (endoplasmic reticulum aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables nascent polypeptide-associated complex binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of nascent polypeptide-associated complex	IDA Inferred from Direct Assay more info	PubMed

NP_012129.1

Ribosome-associated, nascent chain binding factor; binds N-terminal region of nascent peptides during translation; recognizes target proteins via its putative metallopeptidase peptide-binding pocket

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The following sections contain reference sequences that belong to a specific genome build. Explain