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    VTC4 Vtc4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VTC4
    Official Full Name
    Vtc4p
    Primary source
    SGD:S000003549
    Locus tag
    YJL012C
    See related
    AllianceGenome:SGD:S000003549; FungiDB:YJL012C; VEuPathDB:YJL012C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PHM3; YJL012C-A
    Summary
    Enables calmodulin binding activity; inositol hexakisphosphate binding activity; and polyphosphate kinase activity. Involved in several processes, including microautophagy; polyphosphate biosynthetic process; and vacuole fusion, non-autophagic. Located in endoplasmic reticulum and vacuolar membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VTC4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (411234..413399, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT3 Neighboring gene Mad3p Neighboring gene DNA-directed RNA polymerase III subunit RPC17 Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae. Bru S, et al. Mol Microbiol, 2016 Aug. PMID 27072996
    2. VTC4 Polyphosphate Polymerase Knockout Increases Stress Resistance of Saccharomyces cerevisiae Cells. Tomashevsky A, et al. Biology (Basel), 2021 May 30. PMID 34070801, Free PMC Article
    3. Transposon insertional mutagenesis in Saccharomyces uvarum reveals trans-acting effects influencing species-dependent essential genes. Sanchez MR, et al. Genome Res, 2019 Mar. PMID 30635343, Free PMC Article
    4. Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction. Pipercevic J, et al. Nat Commun, 2023 May 8. PMID 37156835, Free PMC Article
    5. Proteins required for vacuolar function are targets of lysine polyphosphorylation in yeast. McCarthy L, et al. FEBS Lett, 2020 Jan. PMID 31466120

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results define Vtc4p* as a polyP-synthesizing enzyme
      Title: Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol hexakisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell periphery HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar transporter chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vtc4p
    NP_012522.2
    • Vacuolar membrane polyphosphate polymerase; subunit of vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      411234..413399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181446.1 → NP_012522.2  TPA: Vtc4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012522.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWG5, P47075, Q7Z872, Q86ZR4
      UniProtKB/TrEMBL
      A6ZPV7, B3LQ90, B5VLG0, C7GSP3, C8ZBJ9, G2WGZ9, N1P0Y9
      Conserved Domains (2) summary
      COG5036
      Location:1 → 497
      COG5036; SPX domain-containing protein involved in vacuolar polyphosphate accumulation [Inorganic ion transport and metabolism, Intracellular trafficking, secretion, and vesicular transport]
      cl09954
      Location:593 → 721
      DUF202; Domain of unknown function (DUF202)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47075.2

    Gene LinkOut

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