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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850670, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000003979
    Locus tag
    YLL056C
    See related
    AllianceGenome:SGD:S000003979; FungiDB:YLL056C; VEuPathDB:YLL056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aldehyde dehydrogenase (NAD+) activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (27409..28305, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cystathionine gamma-synthase Neighboring gene sulfonate dioxygenase Neighboring gene Yct1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YLL056C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity. Wang HY, et al. Appl Microbiol Biotechnol, 2017 Jun. PMID 28265724
    2. Resistance of Saccharomyces cerevisiae to high concentrations of furfural is based on NADPH-dependent reduction by at least two oxireductases. Heer D, et al. Appl Environ Microbiol, 2009 Dec. PMID 19854918, Free PMC Article
    3. The VFH1 (YLL056C) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae. Nguyen TTM, et al. Yeast, 2018 Jul. PMID 29575020
    4. Functional Analysis of six novel ORFs on the left arm of Chromosome XII of Saccharomyces cerevisiae reveals three of them responding to S-starvation. Zhang N, et al. Yeast, 2001 Mar 15. PMID 11223942
    5. Mechanisms of patulin toxicity under conditions that inhibit yeast growth. Iwahashi Y, et al. J Agric Food Chem, 2006 Mar 8. PMID 16506856

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of YLL056C(VFH1) is significantly induced at the protein level by severe vanillin stress in Saccharomyces cerevisiae. VFH1 promoter enables the protein synthesis of other genes including GFP and ALD6 under severe vanillin stress. Null mutant of VFH1 delays growth in the presence of vanillin, furfural and 5-hydroxymethylfural, indicating the importance of Vfh1 for sufficient tolerance against these inhibitors.
      Title: The VFH1 (YLL056C) promoter is vanillin-inducible and enables mRNA translation despite pronounced translation repression caused by severe vanillin stress in Saccharomyces cerevisiae.
    2. study reports ORF YLL056C was significantly upregulated under high furfural or 5-(hydroxymethyl)-2-furaldehyde concentrations; this ORF encoded a protein (Yll056cp), which was grouped into the atypical subgroup 7 in the short-chain dehydrogenase/reductase family and localized to the cytoplasm
      Title: YLL056C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_013044.1
    • NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      27409..28305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181876.1 → NP_013044.1  TPA: uncharacterized protein YLL056C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXV2, Q12177
      UniProtKB/TrEMBL
      A7A0K4, C7GND9, G2WIE4
      Conserved Domains (1) summary
      cd05262
      Location:1 → 291
      SDR_a7; atypical (a) SDRs, subgroup 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12177.1

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