Traf3ip3 TRAF3 interacting protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traf3ip3provided by MGI
Official Full Name: TRAF3 interacting protein 3provided by MGI
Primary source: MGI:MGI:2441706
See related: Ensembl:ENSMUSG00000037318 AllianceGenome:MGI:2441706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T3jam; 6030423D04Rik
Summary: Predicted to enable protein-macromolecule adaptor activity and zf-TRAF domain binding activity. Acts upstream of or within several processes, including antiviral innate immune response; cellular response to cytokine stimulus; and positive regulation of type I interferon production. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including cerebral cortex; eye; foregut; limb segment; and vertebral axis musculature. Orthologous to human TRAF3IP3 (TRAF3 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 26.7), spleen adult (RPKM 17.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 97.62 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (192857812..192883854, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (193175504..193201546, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway.
Title: TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway.
Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA virus-triggered IFN-I production and reduced susceptibility to virus.
Title: TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination.
results define TRAF3IP3 as a metabolic regulator in T reg cell stability and function and suggest a lysosome-specific mTORC1 signaling mechanism that regulates T reg cell metabolism.
Title: Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome.
High T3JAM expression is associated with inflammation.
Title: TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts.
TRAF3IP3 contributes to marginal zone B cell survival by up-regulating autophagy, thereby promoting the T cell-independent type II immune response.
Title: TRAF3IP3, a novel autophagy up-regulated gene, is involved in marginal zone B lymphocyte development and survival.
TRAF3IP3 regulates T cell development and functions in a Golgi-specific ERK signaling mechanism regulating thymocyte development.
Title: T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi.
TRAF2 and TRAF3 were shown to function in a cooperative and nonredundant manner to suppress nuclear factor-kappaB2 (NF-kappaB2) activation, gene expression, and survival in mature B cells.
Title: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI115021 (e-PCR)
- UniSTS:165137

NoName (e-PCR)
- UniSTS:492309

BE196897 (e-PCR)
- UniSTS:207275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables zf-TRAF domain binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to interferon-alpha	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to interferon-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein homodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TRAF3-interacting JNK-activating modulator

Names: TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.