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    Ap1g2 adaptor protein complex AP-1, gamma 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11766, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap1g2provided by MGI
    Official Full Name
    adaptor protein complex AP-1, gamma 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1328307
    See related
    Ensembl:ENSMUSG00000040701 AllianceGenome:MGI:1328307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G2ad; Adtg2
    Summary
    This gene encodes the gamma-2 subunit of the adaptor protein complex 1 (AP-1). AP-1 complex is a heterotetramer comprised of two heavy and one each of medium and small subunits. The encoded protein is a heavy subunit of AP-1 complex that regulates polarized sorting of cargo at the trans-Golgi network and endosomes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 25.5), large intestine adult (RPKM 24.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ap1g2 in Genome Data Viewer
    Location:
    14 C3; 14 28.07 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55336292..55344050, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55098835..55106593, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_36756 Neighboring gene zinc finger homeobox 2 Neighboring gene zinc finger homeobox 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_36762 Neighboring gene STARR-positive B cell enhancer ABC_E11569 Neighboring gene STARR-positive B cell enhancer ABC_E9405 Neighboring gene thiamine triphosphatase Neighboring gene junctophilin 4 Neighboring gene predicted gene, 53860

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and localization of a novel gamma-adaptin-like molecule. Lewin DA, et al. FEBS Lett, 1998 Sep 18. PMID 9762922
    2. Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes. Muthusamy N, et al. J Neurochem, 2012 Oct. PMID 22650988, Free PMC Article
    3. γ2 and γ1AP-1 complexes: Different essential functions and regulatory mechanisms in clathrin-dependent protein sorting. Zizioli D, et al. Eur J Cell Biol, 2017 Jun. PMID 28372831
    4. Identification and characterization of novel clathrin adaptor-related proteins. Takatsu H, et al. J Biol Chem, 1998 Sep 18. PMID 9733768
    5. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Liu K, et al. Sci Rep, 2016 Feb 16. PMID 26880306, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118107

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-1 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    AP-1 complex subunit gamma-like 2
    Names
    gamma 2-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303502.1 → NP_001290431.1  AP-1 complex subunit gamma-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001290431.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region and uses an alternate translation start site, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC157212, AK151844
      UniProtKB/TrEMBL
      Q3U9D1
      Conserved Domains (2) summary
      smart00809
      Location:464 → 572
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:2 → 361
      Adaptin_N; Adaptin N terminal region

    2. NM_007455.5 → NP_031481.2  AP-1 complex subunit gamma-like 2 isoform 1

      See identical proteins and their annotated locations for NP_031481.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC157212, AK151844
      Consensus CDS
      CCDS36929.1
      UniProtKB/Swiss-Prot
      O88512, Q2YDV3
      UniProtKB/TrEMBL
      Q3U9D1, Q3UHW6
      Related
      ENSMUSP00000043996.9, ENSMUST00000036041.15
      Conserved Domains (2) summary
      smart00809
      Location:678 → 786
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:24 → 575
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55336292..55344050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88512.2 GenPept UniProtKB/Swiss-Prot:O88512

    Gene LinkOut

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