Slc28a2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc28a2provided by MGI
Official Full Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 2provided by MGI
Primary source: MGI:MGI:1913105
See related: Ensembl:ENSMUSG00000027219 AllianceGenome:MGI:1913105
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnt2; SPNT; B430217P18; 2010208B10Rik
Summary: Enables purine nucleoside transmembrane transporter activity. Predicted to be involved in several processes, including nucleoside transport; protein localization to cell surface; and purine nucleobase transmembrane transport. Located in brush border membrane. Is expressed in foregut-midgut junction; midgut; and placenta. Orthologous to human SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 25.8), large intestine adult (RPKM 20.5) and 7 other tissues See more
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Genomic context

Location:: 2 E5; 2 60.63 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (122256836..122291633)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (122426357..122461152)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells.
Title: The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells.
It is a purine nucleoside preferring transporter playing a central role in the gastrointestinal absorption of purines in the enterocytes.
Title: Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.
Data concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes.
Title: Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes.
TGF-beta1 transcriptionally activates the CNT2-encoding gene in a JNK-dependent manner.
Title: TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

Slc28a2 (e-PCR), detects polymorphism
- UniSTS:462698

BB152493 (e-PCR)
- UniSTS:185491

Slc28a2 (e-PCR), detects polymorphism
- UniSTS:547067

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleoside:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleobase transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleoside transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables purine nucleoside transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables purine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within purine nucleoside transmembrane transport	TAS Traceable Author Statement more info	PubMed
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in retina homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in retina homeostasis	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/nucleoside cotransporter 2

Names: Na(+)/nucleoside cotransporter 2; concentrative nucleoside transporter 2; purine-selective Na+ nucleoside cotransporter; sodium/purine nucleoside cotransporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356532.3 → NP_001343461.1 sodium/nucleoside cotransporter 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AL844566

Consensus CDS

CCDS16663.1

UniProtKB/Swiss-Prot

O88627, Q8BJP1

UniProtKB/TrEMBL

Q7TMQ0

Conserved Domains (1) summary

TIGR00804
Location:176 → 587

nupC; nucleoside transporter
NM_001379459.1 → NP_001366388.1 sodium/nucleoside cotransporter 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AL844566

UniProtKB/Swiss-Prot

O88627, Q8BJP1

UniProtKB/TrEMBL

Q7TMQ0

Conserved Domains (1) summary

TIGR00804
Location:176 → 587

nupC; nucleoside transporter
NM_001379460.1 → NP_001366389.1 sodium/nucleoside cotransporter 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AL844566

UniProtKB/Swiss-Prot

O88627, Q8BJP1

UniProtKB/TrEMBL

Q7TMQ0

Conserved Domains (1) summary

TIGR00804
Location:176 → 587

nupC; nucleoside transporter
NM_172980.4 → NP_766568.1 sodium/nucleoside cotransporter 2

See identical proteins and their annotated locations for NP_766568.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.

Source sequence(s)

AL844566

Consensus CDS

CCDS16663.1

UniProtKB/Swiss-Prot

O88627, Q8BJP1

UniProtKB/TrEMBL

Q7TMQ0

Related

ENSMUSP00000106154.2, ENSMUST00000110525.8

Conserved Domains (1) summary

TIGR00804
Location:176 → 587

nupC; nucleoside transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

122256836..122291633

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162243.1 → XP_036018136.1 sodium/nucleoside cotransporter 2 isoform X1

UniProtKB/Swiss-Prot

O88627, Q8BJP1

UniProtKB/TrEMBL

Q7TMQ0

Conserved Domains (1) summary

TIGR00804
Location:176 → 587

nupC; nucleoside transporter
XM_011239577.4 → XP_011237879.1 sodium/nucleoside cotransporter 2 isoform X3

Conserved Domains (1) summary

TIGR00804
Location:176 → 509

nupC; nucleoside transporter
XM_036162242.1 → XP_036018135.1 sodium/nucleoside cotransporter 2 isoform X1

UniProtKB/Swiss-Prot

O88627, Q8BJP1

UniProtKB/TrEMBL

Q7TMQ0

Related

ENSMUSP00000106153.2, ENSMUST00000110524.2

Conserved Domains (1) summary

TIGR00804
Location:176 → 587

nupC; nucleoside transporter
XM_036162244.1 → XP_036018137.1 sodium/nucleoside cotransporter 2 isoform X2

UniProtKB/TrEMBL

Q7TMQ0

Conserved Domains (1) summary

TIGR00804
Location:96 → 507

nupC; nucleoside transporter