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    Ppp4r2 protein phosphatase 4, regulatory subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 232314, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp4r2provided by MGI
    Official Full Name
    protein phosphatase 4, regulatory subunit 2provided by MGI
    Primary source
    MGI:MGI:3027896
    See related
    Ensembl:ENSMUSG00000052144 AllianceGenome:MGI:3027896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230060M08Rik
    Summary
    Predicted to enable protein phosphatase regulator activity and protein-macromolecule adaptor activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including genitourinary system; gut; immune system; liver and biliary system; and nervous system. Orthologous to human PPP4R2 (protein phosphatase 4 regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 16.8), CNS E14 (RPKM 12.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp4r2 in Genome Data Viewer
    Location:
    6 D3; 6 46.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (100810596..100846891)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (100833620..100869934)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16870 Neighboring gene SHQ1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer mm9_chr6:100621045-100621346 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene glucoside xylosyltransferase 2 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1325 Neighboring gene STARR-positive B cell enhancer ABC_E2197 Neighboring gene STARR-seq mESC enhancer starr_16873 Neighboring gene STARR-seq mESC enhancer starr_16877 Neighboring gene STARR-seq mESC enhancer starr_16880 Neighboring gene transmembrane protein 258 pseudogene Neighboring gene PDZ domain containing RING finger 3 Neighboring gene predicted gene, 26911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Yoon YS, et al. Proc Natl Acad Sci U S A, 2010 Oct 12. PMID 20876121, Free PMC Article
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase 4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase 4 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418205.1 → NP_001405134.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155648

    2. NM_001418206.1 → NP_001405135.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155648

    3. NM_001418207.1 → NP_001405136.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155648

    4. NM_001418208.1 → NP_001405137.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC155648

    5. NM_001418209.1 → NP_001405138.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC155648
      Related
      ENSMUSP00000145102.2, ENSMUST00000203580.2

    6. NM_001418210.1 → NP_001405139.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC155648

    7. NM_182939.5 → NP_891984.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform a

      See identical proteins and their annotated locations for NP_891984.1

      Status: VALIDATED

      Source sequence(s)
      AC155648
      Consensus CDS
      CCDS20391.1
      UniProtKB/Swiss-Prot
      Q0VGB7, Q4G0D4, Q6P6N7, Q6PHU6, Q8BUU5
      UniProtKB/TrEMBL
      A0A0R4J0U2
      Related
      ENSMUSP00000066314.5, ENSMUST00000063854.7
      Conserved Domains (1) summary
      pfam09184
      Location:6 → 258
      PPP4R2; PPP4R2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      100810596..100846891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VGB7.1 GenPept UniProtKB/Swiss-Prot:Q0VGB7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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