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    PRP46 mRNA splicing protein PRP46 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRP46
    Official Full Name
    mRNA splicing protein PRP46
    Primary source
    SGD:S000006072
    Locus tag
    YPL151C
    See related
    AllianceGenome:SGD:S000006072; FungiDB:YPL151C; VEuPathDB:YPL151C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NTC50
    Summary
    Involved in mRNA splicing, via spliceosome. Part of Prp19 complex and spliceosomal complex. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRP46 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (266180..267535, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene peptidylprolyl isomerase RRD2 Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Atg5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Spliceosome: A Protein-Directed Metalloribozyme. Shi Y. J Mol Biol, 2017 Aug 18. PMID 28733144
    2. RPA resolves conflicting activities of accessory proteins during reconstitution of Dmc1-mediated meiotic recombination. Chan YL, et al. Nucleic Acids Res, 2019 Jan 25. PMID 30462332, Free PMC Article
    3. Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates. Gahura O, et al. J Cell Biochem, 2009 Jan 1. PMID 19016306
    4. Decrypting the Information Exchange Pathways across the Spliceosome Machinery. Saltalamacchia A, et al. J Am Chem Soc, 2020 May 6. PMID 32275149, Free PMC Article
    5. Characterization of interactions among the Cef1p-Prp19p-associated splicing complex. Ohi MD, et al. RNA, 2002 Jun. PMID 12088152, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA splicing protein PRP46
    NP_015174.1
    • Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      266180..267535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183965.1 → NP_015174.1  TPA: mRNA splicing protein PRP46 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015174.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3L8, Q12417
      UniProtKB/TrEMBL
      A6ZWA3, C8ZIM8, G2WP32, N1NW12
      Conserved Domains (2) summary
      cd00200
      Location:131 → 427
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:144 → 180
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12417.1

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