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    FDCSP follicular dendritic cell secreted protein [ Homo sapiens (human) ]

    Gene ID: 260436, updated on 10-Dec-2024

    Summary

    Official Symbol
    FDCSPprovided by HGNC
    Official Full Name
    follicular dendritic cell secreted proteinprovided by HGNC
    Primary source
    HGNC:HGNC:19215
    See related
    Ensembl:ENSG00000181617 MIM:607241; AllianceGenome:HGNC:19215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C4orf7; FDC-SP
    Summary
    This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
    Expression
    Biased expression in salivary gland (RPKM 447.2), lymph node (RPKM 235.7) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FDCSP in Genome Data Viewer
    Location:
    4q13.3; 4q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70226124..70235252)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73565445..73574935)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71091841..71100969)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377270 Neighboring gene odontogenic, ameloblast associated Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71086538-71086690 Neighboring gene casein kappa Neighboring gene calcium binding protein, spermatid associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC71894

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    follicular dendritic cell secreted peptide
    Names
    FDC secreted protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152997.4NP_694542.1  follicular dendritic cell secreted peptide precursor

      See identical proteins and their annotated locations for NP_694542.1

      Status: REVIEWED

      Source sequence(s)
      AY190326
      Consensus CDS
      CCDS3537.1
      UniProtKB/Swiss-Prot
      Q8NFU4
      UniProtKB/TrEMBL
      Q540F3
      Related
      ENSP00000318437.5, ENST00000317987.6
      Conserved Domains (1) summary
      pfam15215
      Location:1882
      FDC-SP; Follicular dendritic cell secreted peptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70226124..70235252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73565445..73574935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)