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    Foxk2 forkhead box K2 [ Mus musculus (house mouse) ]

    Gene ID: 68837, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxk2provided by MGI
    Official Full Name
    forkhead box K2provided by MGI
    Primary source
    MGI:MGI:1916087
    See related
    Ensembl:ENSMUSG00000039275 AllianceGenome:MGI:1916087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ILF; Ilf1; 1110054H05Rik; 5730434B08Rik; 6230415M23Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including intracellular glucose homeostasis; negative regulation of autophagy; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including blastocyst; nervous system; reproductive system; and urinary system. Orthologous to human FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 17.4), ovary adult (RPKM 17.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Foxk2 in Genome Data Viewer
    Location:
    11 E2; 11 85.15 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121150805..121200726)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121259987..121309900)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hexosaminidase D Neighboring gene STARR-positive B cell enhancer ABC_E5315 Neighboring gene STARR-seq mESC enhancer starr_31378 Neighboring gene STARR-positive B cell enhancer ABC_E8883 Neighboring gene cytochrome b 245 chaperone 1 Neighboring gene nuclear prelamin A recognition factor Neighboring gene WD repeat domain 45B Neighboring gene Rab40B, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_31380 Neighboring gene microRNA 7236

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    forkhead box protein K2
    Names
    cellular transcription factor ILF-1
    interleukin enhancer-binding factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080932.3NP_001074401.2  forkhead box protein K2 isoform 1

      See identical proteins and their annotated locations for NP_001074401.2

      Status: VALIDATED

      Source sequence(s)
      AL808021, EU882160
      Consensus CDS
      CCDS36393.2
      UniProtKB/Swiss-Prot
      A2AN27, B5AZX0, Q3UCQ1
      Related
      ENSMUSP00000101719.2, ENSMUST00000106113.2
      Conserved Domains (2) summary
      cd00060
      Location:41145
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:249335
      Forkhead; Forkhead domain
    2. NM_001363033.1NP_001349962.1  forkhead box protein K2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK150439, AL808021
      Conserved Domains (2) summary
      cd00060
      Location:41145
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:249334
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      121150805..121200726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156941.1XP_036012834.1  forkhead box protein K2 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:341562
      PHA03247; large tegument protein UL36; Provisional
      cd00060
      Location:41145
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd20055
      Location:247344
      FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins
    2. XM_036156942.1XP_036012835.1  forkhead box protein K2 isoform X6

      Conserved Domains (2) summary
      cd00060
      Location:41145
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd20055
      Location:247344
      FH_FOXK2; Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins
    3. XM_011249218.2XP_011247520.1  forkhead box protein K2 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:380683
      PHA03247; large tegument protein UL36; Provisional
      COG5025
      Location:175381
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00060
      Location:41124
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:287373
      Forkhead; Forkhead domain
    4. XM_011249219.2XP_011247521.1  forkhead box protein K2 isoform X2

      Conserved Domains (4) summary
      PHA03247
      Location:380657
      PHA03247; large tegument protein UL36; Provisional
      COG5025
      Location:175381
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00060
      Location:41124
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:287373
      Forkhead; Forkhead domain
    5. XM_011249220.2XP_011247522.1  forkhead box protein K2 isoform X4

      Conserved Domains (3) summary
      COG5025
      Location:175381
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00060
      Location:41124
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:287373
      Forkhead; Forkhead domain
    6. XM_011249221.2XP_011247523.1  forkhead box protein K2 isoform X5

      Conserved Domains (3) summary
      COG5025
      Location:175381
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00060
      Location:41124
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:287373
      Forkhead; Forkhead domain

    RNA

    1. XR_004937017.1 RNA Sequence

    2. XR_003949496.2 RNA Sequence

    3. XR_004937014.1 RNA Sequence

    4. XR_879734.2 RNA Sequence

    5. XR_004937015.1 RNA Sequence

    6. XR_003949497.2 RNA Sequence

    7. XR_004937016.1 RNA Sequence

    8. XR_004937018.1 RNA Sequence