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    Apex1 apurinic/apyrimidinic endonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 11792, updated on 9-Dec-2024

    Summary

    Official Symbol
    Apex1provided by MGI
    Official Full Name
    apurinic/apyrimidinic endonuclease 1provided by MGI
    Primary source
    MGI:MGI:88042
    See related
    Ensembl:ENSMUSG00000035960 AllianceGenome:MGI:88042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APE; Apex; HAP1; Ref-1
    Summary
    Predicted to enable several functions, including DNA binding activity; NF-kappaB binding activity; and nuclease activity. Acts upstream of or within cell redox homeostasis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; autopod; early conceptus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 76.3), CNS E14 (RPKM 49.8) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Apex1 in Genome Data Viewer
    Location:
    14 C1; 14 26.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51162406..51164645)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50924949..50927188)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene kelch-like 33 Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene Apex1 promoter region Neighboring gene STARR-seq mESC enhancer starr_36659 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7308 Neighboring gene predicted gene, 52117 Neighboring gene purine-nucleoside phosphorylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3'-5'-DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3'-5'-DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-(abasic site) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-(abasic site) binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded DNA 3'-5' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA exodeoxyribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA exodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoric diester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables site-specific endodeoxyribonuclease activity, specific for altered base ISO
    Inferred from Sequence Orthology
    more info
     
    enables site-specific endodeoxyribonuclease activity, specific for altered base ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via base-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telomere maintenance via base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA repair nuclease/redox regulator APEX1
    Names
    AP endonuclease 1
    APEN
    APEX nuclease
    DNA-(apurinic or apyrimidinic site) endonuclease
    DNA-(apurinic or apyrimidinic site) lyase
    redox factor-1
    NP_033817.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009687.2NP_033817.1  DNA repair nuclease/redox regulator APEX1

      See identical proteins and their annotated locations for NP_033817.1

      Status: VALIDATED

      Source sequence(s)
      AC027184, BC052401
      Consensus CDS
      CCDS27027.1
      UniProtKB/Swiss-Prot
      P28352
      UniProtKB/TrEMBL
      F6QA74, Q544Z7
      Related
      ENSMUSP00000042602.6, ENSMUST00000049411.12
      Conserved Domains (1) summary
      cd09087
      Location:61315
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51162406..51164645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)