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    Pde12 phosphodiesterase 12 [ Mus musculus (house mouse) ]

    Gene ID: 211948, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pde12provided by MGI
    Official Full Name
    phosphodiesterase 12provided by MGI
    Primary source
    MGI:MGI:2443226
    See related
    Ensembl:ENSMUSG00000043702 AllianceGenome:MGI:2443226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2-PDE; 2'-PDE; E430028B21Rik
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including cellular response to interferon-alpha; innate immune response; and mRNA catabolic process. Located in mitochondrion. Is expressed in brain; foregut; genitourinary system; and skin. Orthologous to human PDE12 (phosphodiesterase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.0), ovary adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pde12 in Genome Data Viewer
    Location:
    14 A3; 14 16.09 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26381113..26390823, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26664117..26669846, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 6A Neighboring gene STARR-seq mESC enhancer starr_36241 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:27489365-27489548 Neighboring gene ARF GTPase 4 Neighboring gene microRNA 7672 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene predicted gene, 34415 Neighboring gene STARR-seq mESC enhancer starr_36242 Neighboring gene STARR-seq mESC enhancer starr_36244 Neighboring gene ankyrin repeat and SOCS box-containing 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-alpha IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    2',5'-phosphodiesterase 12
    Names
    2'-phosphodiesterase
    mitochondrial deadenylase
    NP_848783.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178668.4NP_848783.3  2',5'-phosphodiesterase 12

      See identical proteins and their annotated locations for NP_848783.3

      Status: VALIDATED

      Source sequence(s)
      AC121919
      Consensus CDS
      CCDS26882.1
      UniProtKB/Swiss-Prot
      Q3TIU4, Q3TTY4, Q6P2L5, Q8BKH8, Q8BTS8, Q8BUQ5
      Related
      ENSMUSP00000059666.10, ENSMUST00000052932.10
      Conserved Domains (1) summary
      cl00490
      Location:298607
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      26381113..26390823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)