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    Retreg1 reticulophagy regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 66270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Retreg1provided by MGI
    Official Full Name
    reticulophagy regulator 1provided by MGI
    Primary source
    MGI:MGI:1913520
    See related
    Ensembl:ENSMUSG00000022270 AllianceGenome:MGI:1913520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam134b; Retreg1d; 1810015C04Rik
    Summary
    Enables endoplasmic reticulum-autophagosome adaptor activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including collagen catabolic process; macroautophagy; and white fat cell differentiation. Located in cis-Golgi network and endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; ganglia; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2B. Orthologous to human RETREG1 (reticulophagy regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 11.8), testis adult (RPKM 10.0) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Retreg1 in Genome Data Viewer
    Location:
    15 B1; 15 9.59 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (25840795..25973782)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (25843298..25973696)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene myosin X Neighboring gene PCNA-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_38176 Neighboring gene STARR-seq mESC enhancer starr_38182 Neighboring gene STARR-seq mESC enhancer starr_38185 Neighboring gene STARR-seq mESC enhancer starr_38189 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 15_175.1 Neighboring gene STARR-seq mESC enhancer starr_38200 Neighboring gene microRNA 7212 Neighboring gene STARR-positive B cell enhancer ABC_E7362 Neighboring gene predicted gene, 53887 Neighboring gene STARR-positive B cell enhancer mm9_chr15:25946080-25946381 Neighboring gene zinc finger protein 622 Neighboring gene STARR-seq mESC enhancer starr_38204 Neighboring gene predicted gene, 41279 Neighboring gene predicted gene, 57625

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endoplasmic reticulum-autophagosome adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    reticulophagy regulator 1
    Names
    family with sequence similarity 134, member B
    protein FAM134B
    reticulophagy receptor 1
    reticulophagy receptor Fam134b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034851.2NP_001030023.1  reticulophagy regulator 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC162303, AK015182, BY779369, CB724233
      Consensus CDS
      CCDS37050.1
      UniProtKB/Swiss-Prot
      E9QPM1, Q7TMY5, Q8VE91, Q9CUJ4, Q9D8Z5
      Related
      ENSMUSP00000022881.8, ENSMUST00000022881.15
      Conserved Domains (1) summary
      pfam02453
      Location:68216
      Reticulon; Reticulon
    2. NM_001277315.1NP_001264244.1  reticulophagy regulator 1 isoform 2

      See identical proteins and their annotated locations for NP_001264244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC162303, AK167327
      Consensus CDS
      CCDS37051.1
      UniProtKB/Swiss-Prot
      Q8VE91
      Related
      ENSMUSP00000154471.2, ENSMUST00000227275.2
      Conserved Domains (1) summary
      cl26593
      Location:319356
      DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    3. NM_001277316.1NP_001264245.1  reticulophagy regulator 1 isoform 3

      See identical proteins and their annotated locations for NP_001264245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC162303, AI645997, AK146972
      Consensus CDS
      CCDS88741.1
      UniProtKB/Swiss-Prot
      Q8VE91
      Related
      ENSMUSP00000154765.2, ENSMUST00000226438.2
      Conserved Domains (2) summary
      TIGR00600
      Location:137248
      rad2; DNA excision repair protein (rad2)
      pfam09849
      Location:327364
      DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    4. NM_001277317.1NP_001264246.1  reticulophagy regulator 1 isoform 4

      See identical proteins and their annotated locations for NP_001264246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC162303, AK007506
      Consensus CDS
      CCDS88742.1
      UniProtKB/Swiss-Prot
      Q8VE91
      Related
      ENSMUSP00000154070.2, ENSMUST00000228306.2
      Conserved Domains (2) summary
      TIGR00600
      Location:119230
      rad2; DNA excision repair protein (rad2)
      pfam09849
      Location:309346
      DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    5. NM_001277318.1NP_001264247.1  reticulophagy regulator 1 isoform 5

      See identical proteins and their annotated locations for NP_001264247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC131178, AC162303
      Conserved Domains (1) summary
      cl41772
      Location:184
      Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins
    6. NM_025459.3NP_079735.2  reticulophagy regulator 1 isoform 2

      See identical proteins and their annotated locations for NP_079735.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC162303
      Consensus CDS
      CCDS37051.1
      UniProtKB/Swiss-Prot
      Q8VE91
      Related
      ENSMUSP00000106068.2, ENSMUST00000110438.3
      Conserved Domains (1) summary
      cl26593
      Location:319356
      DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      25840795..25973782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159536.1XP_036015429.1  reticulophagy regulator 1 isoform X1

      Conserved Domains (1) summary
      cd22560
      Location:50242
      RETR1_RHD; N-terminal reticulon-homology domain of Reticulophagy regulator 1
    2. XM_036159537.1XP_036015430.1  reticulophagy regulator 1 isoform X3

      Conserved Domains (1) summary
      cl41772
      Location:184
      Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins
    3. XM_006520134.5XP_006520197.1  reticulophagy regulator 1 isoform X2

      See identical proteins and their annotated locations for XP_006520197.1

      UniProtKB/Swiss-Prot
      Q8VE91
      Conserved Domains (1) summary
      cl26593
      Location:319356
      DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)